Otegal
Generic Name
Ofloxacin + Ornidazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| otegal 150 mg capsule | ৳ 170.00 | ৳ 1,700.00 |
Description
Overview of the medicine
Otegal is a broad-spectrum antibiotic combination containing Ofloxacin, a fluoroquinolone, and Ornidazole, a nitroimidazole. It is used to treat various bacterial and protozoal infections.
Uses & Indications
Dosage
Adults
Usually one Otegal tablet (Ofloxacin 200 mg + Ornidazole 500 mg) orally twice daily for 5-7 days, depending on the infection severity.
Elderly
No specific dose adjustment is usually required for elderly patients unless there is significant renal impairment.
Renal_impairment
Dose adjustment is necessary for patients with impaired renal function. Consult physician for specific guidelines.
How to Take
To be taken orally, preferably with or after meals to minimize gastrointestinal discomfort.
Mechanism of Action
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential for DNA replication, transcription, repair, and recombination. Ornidazole is converted to reactive metabolites that damage microbial DNA, leading to cell death.
Pharmacokinetics
Onset
Therapeutic concentrations are generally achieved within 1-2 hours for Ofloxacin and similar for Ornidazole.
Excretion
Ofloxacin is primarily excreted unchanged via the kidneys. Ornidazole is excreted via both renal and fecal routes.
Half life
Ofloxacin has a half-life of 4-6 hours, while Ornidazole has a longer half-life of 12-14 hours.
Absorption
Both Ofloxacin and Ornidazole are rapidly and well absorbed from the gastrointestinal tract after oral administration.
Metabolism
Ofloxacin is minimally metabolized; Ornidazole is extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin, Ornidazole, or other fluoroquinolones/nitroimidazoles
- History of epilepsy or other CNS disorders
- First trimester of pregnancy (due to Ornidazole)
- Children and adolescents (due to Ofloxacin)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Theophylline
Increased plasma levels of Theophylline, risk of toxicity.
Cimetidine, Phenytoin, Barbiturates
May affect the metabolism of Ornidazole.
Antacids containing magnesium/aluminum
May decrease the absorption of Ofloxacin. Administer at least 2 hours apart.
Storage
Store in a cool, dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, confusion, seizures, and abdominal discomfort. Treatment involves gastric lavage, activated charcoal, and supportive measures. No specific antidote exists.
Pregnancy & Lactation
Generally not recommended during pregnancy, especially in the first trimester due to Ornidazole. Use only if potential benefit justifies potential risk to the fetus. Avoid during lactation as both components pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin, Ornidazole, or other fluoroquinolones/nitroimidazoles
- History of epilepsy or other CNS disorders
- First trimester of pregnancy (due to Ornidazole)
- Children and adolescents (due to Ofloxacin)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Theophylline
Increased plasma levels of Theophylline, risk of toxicity.
Cimetidine, Phenytoin, Barbiturates
May affect the metabolism of Ornidazole.
Antacids containing magnesium/aluminum
May decrease the absorption of Ofloxacin. Administer at least 2 hours apart.
Storage
Store in a cool, dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, confusion, seizures, and abdominal discomfort. Treatment involves gastric lavage, activated charcoal, and supportive measures. No specific antidote exists.
Pregnancy & Lactation
Generally not recommended during pregnancy, especially in the first trimester due to Ornidazole. Use only if potential benefit justifies potential risk to the fetus. Avoid during lactation as both components pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
Clinical Trials
The efficacy and safety of Ofloxacin and Ornidazole combination have been established through various clinical trials for indicated infections.
Lab Monitoring
- Monitor renal and hepatic function during prolonged therapy.
- Monitor INR in patients receiving warfarin concurrently.
Doctor Notes
- Advise patients about potential CNS and musculoskeletal adverse effects, especially elderly.
- Caution in patients with a history of seizures or renal impairment.
- Emphasize completion of full course and avoidance of alcohol.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not skip doses or stop treatment early.
- Avoid alcohol consumption during and for at least 48 hours after treatment.
- Report any severe side effects immediately to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness, confusion, or visual disturbances. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Follow a balanced diet.
- Avoid excessive sun exposure as Ofloxacin can cause photosensitivity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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