Oticlor
Generic Name
Cefaclor
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oticlor 500 mg capsule | ৳ 40.00 | ৳ 160.00 |
Description
Overview of the medicine
Oticlor 500 mg Capsule contains Cefaclor, a second-generation cephalosporin antibiotic used to treat various bacterial infections including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and otitis media.
Uses & Indications
Dosage
Adults
Typical adult dosage is 250 mg to 500 mg every 8 hours. Max 4 g/day.
Elderly
Dosage adjustment not generally necessary unless severe renal impairment is present.
Renal_impairment
For severe renal impairment (creatinine clearance < 10 mL/min), initial dose is as usual, subsequent doses may be reduced or frequency extended.
How to Take
Administer orally. May be taken with or without food. Taking with food may minimize gastrointestinal upset.
Mechanism of Action
Cefaclor is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to osmotic instability and cell lysis.
Pharmacokinetics
Onset
Clinical effects typically observed within hours to days, depending on the infection.
Excretion
Mainly via the kidneys by glomerular filtration and tubular secretion. Approximately 60-85% of the dose is excreted unchanged in urine within 8 hours.
Half life
Approximately 0.5-1 hour in individuals with normal renal function.
Absorption
Well absorbed from the gastrointestinal tract (approximately 60-85%). Peak plasma concentrations are reached within 0.5-1 hour after administration.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefaclor or other cephalosporins
- History of severe hypersensitivity reaction to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. Monitor INR/PT.
Probenecid
Increases cefaclor plasma levels and prolongs its half-life by inhibiting renal excretion.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management is primarily supportive; activated charcoal may be given. Hemodialysis is generally not effective.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy; benefits should outweigh risks. Cefaclor is excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, refer to packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of cefaclor for various bacterial infections since its introduction.
Lab Monitoring
- Monitor renal function (creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
- Monitor INR/PT if co-administered with warfarin.
Doctor Notes
- Advise patients to complete the full course to prevent resistance.
- Be aware of potential cross-reactivity with penicillin allergies.
- Monitor for signs of C. difficile infection if prolonged diarrhea occurs.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Do not share this medication with others.
- Contact your doctor if symptoms worsen or new symptoms appear.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol consumption during treatment.
- Report any severe or persistent side effects to your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.