Ovanil
Generic Name
ovanil-40-mg-syrup
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ovanil 40 mg syrup | ৳ 14.00 | N/A |
Description
Overview of the medicine
Ovanil 40 mg Syrup, containing Montelukast, is an oral medication primarily used for the prevention and long-term treatment of asthma and for the relief of symptoms of seasonal and perennial allergic rhinitis. It works by blocking leukotrienes, substances in the body that cause inflammation, swelling, and narrowing of airways.
Uses & Indications
Dosage
Adults
The usual dose for adults and adolescents 15 years and older for asthma or allergic rhinitis is 10 mg (an appropriate volume of Ovanil 40 mg Syrup as prescribed by a physician) once daily, preferably in the evening.
Pediatric
Children 6 to 14 years: 5 mg (an appropriate volume of Ovanil 40 mg Syrup) once daily in the evening. Children 2 to 5 years: 4 mg (an appropriate volume of Ovanil 40 mg Syrup) once daily in the evening. Children 6 months to 2 years: 4 mg (an appropriate volume of Ovanil 40 mg Syrup) once daily in the evening for asthma or perennial allergic rhinitis.
Renal_impairment
No dosage adjustment is necessary for patients with renal insufficiency.
How to Take
Ovanil 40 mg Syrup is for oral administration. It should be taken once daily in the evening, with or without food. For asthma, the dose should be taken in the evening. For allergic rhinitis, the time of administration may be individualized to suit patient needs.
Mechanism of Action
Montelukast selectively blocks the cysteinyl leukotriene 1 (CysLT1) receptor. Leukotrienes are potent inflammatory mediators that are released from various cells, including mast cells and eosinophils, and bind to CysLT1 receptors, causing bronchoconstriction, mucous secretion, vascular permeability, and eosinophil recruitment. By blocking these receptors, Montelukast inhibits these actions, improving respiratory function and reducing allergic symptoms.
Pharmacokinetics
Onset
Bronchodilation within 1 hour; clinical effects usually seen within one day for asthma.
Excretion
Primarily excreted in the feces via bile (approximately 86%), with minimal renal excretion.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations achieved in 2-4 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP3A4, CYP2C9, CYP2A6).
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
Drug Interactions
Rifampin
Decreases the AUC of Montelukast by approximately 40%. Concomitant administration is not recommended.
Phenobarbital
Decreases the area under the curve (AUC) of Montelukast by approximately 40%.
Storage
Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Montelukast.
Pregnancy & Lactation
Pregnancy Category B. Montelukast should be used during pregnancy only if clearly needed. It is not known whether Montelukast is excreted in human milk, therefore caution should be exercised when Ovanil 40 mg Syrup is administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
Drug Interactions
Rifampin
Decreases the AUC of Montelukast by approximately 40%. Concomitant administration is not recommended.
Phenobarbital
Decreases the area under the curve (AUC) of Montelukast by approximately 40%.
Storage
Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Montelukast.
Pregnancy & Lactation
Pregnancy Category B. Montelukast should be used during pregnancy only if clearly needed. It is not known whether Montelukast is excreted in human milk, therefore caution should be exercised when Ovanil 40 mg Syrup is administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved in many countries including Bangladesh for Montelukast
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Montelukast, the active ingredient in Ovanil 40 mg Syrup, has undergone extensive clinical trials demonstrating its efficacy and safety for asthma and allergic rhinitis across various age groups.
Lab Monitoring
- Routine laboratory monitoring is generally not required for Montelukast.
Doctor Notes
- Counsel patients and caregivers regarding potential neuropsychiatric adverse effects, including changes in mood, behavior, or suicidal ideation.
- Emphasize daily evening dosing for optimal asthma control and adherence.
- Not indicated for acute asthma exacerbations.
Patient Guidelines
- Take Ovanil 40 mg Syrup once daily in the evening, even if you feel well.
- Do not stop taking the medicine suddenly without consulting your doctor.
- This medicine is not for treating acute asthma attacks; use a quick-relief inhaler for that.
- Inform your doctor immediately if you experience any mood or behavior changes.
Missed Dose Advice
If a dose of Ovanil 40 mg Syrup is missed, the patient should take the next dose at the regular time. Do not take a double dose to make up for a missed dose.
Driving Precautions
Ovanil 40 mg Syrup may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Identify and avoid asthma and allergy triggers.
- Maintain a healthy lifestyle with regular exercise (if appropriate) and a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.