Oxecylin
Generic Name
Oxytetracycline
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxecylin 250 mg capsule | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Oxecylin 250 mg Capsule contains oxytetracycline, a broad-spectrum antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
250-500 mg every 6-12 hours, depending on the severity of infection.
Elderly
Dosage adjustment may be necessary in elderly patients with impaired renal function.
Renal_impairment
Dosage reduction is required in patients with severe renal impairment.
How to Take
Take capsules with a full glass of water, preferably on an empty stomach (1 hour before or 2 hours after meals). Avoid taking with dairy products, antacids, or iron preparations.
Mechanism of Action
Oxytetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex.
Pharmacokinetics
Onset
Clinical effects typically observed within hours to days, depending on the infection.
Excretion
Primarily excreted unchanged in urine and feces.
Half life
Approximately 6-10 hours.
Absorption
Incompletely absorbed from the GI tract (about 60-80%), bioavailability reduced by food, dairy, and antacids.
Metabolism
Minimally metabolized by the liver.
Side Effects
Contraindications
- •Hypersensitivity to tetracyclines
- •Children under 8 years of age (due to potential for permanent tooth discoloration and bone growth inhibition)
- •Severe renal impairment (unless dosage is carefully adjusted)
- •Pregnancy and lactation
Drug Interactions
Penicillins
Antagonistic effect.
Anticoagulants
May potentiate the effect of anticoagulants.
Oral Contraceptives
May reduce efficacy of oral contraceptives.
Antacids/Iron/Calcium
Reduce absorption of oxytetracycline.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include gastrointestinal upset, nephrotoxicity, and hepatotoxicity. Treatment is supportive, including gastric lavage or induced emesis, and symptomatic management.
Pregnancy & Lactation
Category D in pregnancy (risk to fetus, permanent tooth discoloration, bone growth inhibition). Not recommended during breastfeeding (excreted in milk, potential for tooth discoloration and bone growth effects in infant).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (refer to product label)
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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