Oxipin
Generic Name
Oxaprozin 300 mg Tablet
Manufacturer
MediPharm Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxipin 300 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Oxipin 300 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders.
Uses & Indications
Dosage
Adults
300 mg once daily, or 150 mg twice daily. Maximum daily dose is 600 mg.
Elderly
Start with lower doses (e.g., 150 mg once daily) due to increased risk of adverse effects.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment. Not recommended for severe renal disease.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Oxaprozin works by inhibiting the activity of cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in the synthesis of prostaglandins. Prostaglandins are chemicals that contribute to pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief usually begins within 1-2 hours.
Excretion
Mainly excreted in the urine (about 60%) and feces (about 35%) as metabolites.
Half life
Approximately 40-60 hours, allowing for once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached within 3-5 hours.
Metabolism
Extensively metabolized in the liver, primarily via oxidation and glucuronidation.
Side Effects
Contraindications
- Known hypersensitivity to oxaprozin or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics
May reduce diuretic effect and increase risk of renal impairment.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors / ARBs
May reduce antihypertensive effect and increase risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy, and gastrointestinal bleeding. In severe cases, acute renal failure, respiratory depression, and coma may occur. Management involves supportive care, gastric lavage, and administration of activated charcoal. Hemodialysis is unlikely to be beneficial.
Pregnancy & Lactation
Oxaprozin should be avoided during pregnancy, especially during the third trimester, due to potential risks to the fetus (e.g., premature closure of the ductus arteriosus). It is also not recommended during breastfeeding as it may pass into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to oxaprozin or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics
May reduce diuretic effect and increase risk of renal impairment.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors / ARBs
May reduce antihypertensive effect and increase risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy, and gastrointestinal bleeding. In severe cases, acute renal failure, respiratory depression, and coma may occur. Management involves supportive care, gastric lavage, and administration of activated charcoal. Hemodialysis is unlikely to be beneficial.
Pregnancy & Lactation
Oxaprozin should be avoided during pregnancy, especially during the third trimester, due to potential risks to the fetus (e.g., premature closure of the ductus arteriosus). It is also not recommended during breastfeeding as it may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Clinical trials for oxaprozin have demonstrated its efficacy and safety in treating various inflammatory and painful conditions, particularly osteoarthritis and rheumatoid arthritis, with a favorable once-daily dosing profile due to its long half-life.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver function tests (LFTs)
- Renal function tests (e.g., Creatinine, BUN)
- Fecal occult blood test (for long-term use)
Doctor Notes
- Consider the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs of gastrointestinal bleeding, renal dysfunction, and cardiovascular adverse events, especially in elderly patients or those with pre-existing conditions.
- Educate patients on potential side effects and when to seek medical attention.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Take with food or milk to prevent stomach upset.
- Report any unusual bleeding, stomach pain, or rash to your doctor immediately.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, drowsiness, or blurred vision. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid activities requiring mental alertness if dizziness occurs.
- Consult your doctor before taking any other pain relievers or NSAIDs.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.