Oxyzolin
Generic Name
Oxyzolin-0025-Nasal-Drop (Oxymetazoline Hydrochloride)
Manufacturer
Local Pharmaceutical Manufacturer
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxyzolin 0025 nasal drop | ৳ 40.00 | N/A |
Description
Overview of the medicine
Oxyzolin 0.025% Nasal Drop is a decongestant used to relieve nasal congestion due to colds, allergies, and hay fever. It helps to clear blocked noses by reducing swelling in the nasal passages.
Uses & Indications
Dosage
Adults
Not recommended for adults; for children 2-6 years old.
Elderly
Not recommended for elderly; for children 2-6 years old. Use with caution if prescribed off-label for specific conditions and monitor cardiovascular status.
Renal_impairment
No specific dosage adjustment required due to minimal systemic absorption; consult physician if using off-label.
How to Take
Clear nasal passages before use. Tilt head back slightly, insert dropper into nostril, and squeeze. Do not touch dropper to nose to avoid contamination. Administer while lying down or sitting with head tilted back. After use, wipe the dropper clean and replace the cap.
Mechanism of Action
Oxymetazoline is an alpha-adrenergic agonist, causing vasoconstriction of the arterioles in the nasal mucosa, thereby reducing swelling and congestion.
Pharmacokinetics
Onset
Within minutes (typically 5-10 minutes).
Excretion
Primarily through urine if systemically absorbed.
Half life
Approximately 5-8 hours systemically, but local decongestant effect lasts longer (up to 10-12 hours).
Absorption
Minimal systemic absorption after topical nasal administration.
Metabolism
Limited, mostly by hepatic enzymes if significant systemic absorption occurs.
Side Effects
Contraindications
- Hypersensitivity to oxymetazoline or any components.
- Transsphenoidal hypophysectomy or other surgery exposing the dura mater.
- Narrow-angle glaucoma.
- Concurrent use with MAO inhibitors or within 14 days of discontinuing them.
Drug Interactions
Beta-blockers
May increase blood pressure.
MAO Inhibitors
Concurrent use may lead to hypertensive crisis.
Tricyclic Antidepressants
May potentiate vasoconstrictor effects.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms may include severe nasal congestion (rhinitis medicamentosa), burning, stinging, sneezing, and increased nasal discharge. Systemic effects like headache, nausea, hypertension, and palpitations are rare but possible with excessive use or ingestion. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use with caution; consult a doctor. Limited data available on safety in pregnancy and lactation. Systemic absorption is minimal, but risks should be weighed against benefits.
Side Effects
Contraindications
- Hypersensitivity to oxymetazoline or any components.
- Transsphenoidal hypophysectomy or other surgery exposing the dura mater.
- Narrow-angle glaucoma.
- Concurrent use with MAO inhibitors or within 14 days of discontinuing them.
Drug Interactions
Beta-blockers
May increase blood pressure.
MAO Inhibitors
Concurrent use may lead to hypertensive crisis.
Tricyclic Antidepressants
May potentiate vasoconstrictor effects.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms may include severe nasal congestion (rhinitis medicamentosa), burning, stinging, sneezing, and increased nasal discharge. Systemic effects like headache, nausea, hypertension, and palpitations are rare but possible with excessive use or ingestion. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use with caution; consult a doctor. Limited data available on safety in pregnancy and lactation. Systemic absorption is minimal, but risks should be weighed against benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date (check product label for exact dates).
Availability
Pharmacies, Drugstores
Approval Status
Approved by regulatory authorities
Patent Status
Generic Available
Clinical Trials
Oxymetazoline has been extensively studied and is widely used. Specific clinical trials for the 'Oxyzolin' brand may vary by manufacturer and region, focusing on bioequivalence and local efficacy.
Lab Monitoring
- No specific routine lab monitoring required.
- Blood pressure monitoring in patients with pre-existing hypertension or cardiovascular disease, especially with prolonged or excessive use.
Doctor Notes
- Educate patients, especially parents, on the correct administration technique and the critical importance of adhering to the recommended duration of use (maximum 3-5 days) to prevent rhinitis medicamentosa.
- Advise patients to seek medical attention if congestion persists or worsens after the recommended usage period, or if systemic symptoms occur.
Patient Guidelines
- Do not exceed recommended dose or frequency.
- Do not use for more than 3-5 consecutive days to avoid rebound congestion (rhinitis medicamentosa).
- Consult a doctor if symptoms persist for more than 7 days or worsen.
- Avoid sharing the bottle to prevent the spread of infection.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it's almost time for the next dose. Do not double the dose to make up for a missed one. Continue with your regular dosing schedule.
Driving Precautions
Generally safe, as systemic absorption is minimal and unlikely to cause drowsiness or impair driving ability. However, if dizziness or other systemic effects occur, avoid driving or operating machinery.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Use saline nasal sprays or washes for gentle cleansing and hydration, especially during extended use of decongestants.
- Avoid irritants like smoke and allergens.
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