Ozole
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ozole 20 mg capsule | ৳ 4.50 | N/A |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor used to reduce stomach acid production and treat conditions like GERD, ulcers, and heartburn.
Uses & Indications
Dosage
Adults
Typical dose is 20 mg orally once daily, preferably in the morning before food. Duration varies based on condition, often 4-8 weeks.
Elderly
No dose adjustment is generally needed, but caution should be exercised in severe hepatic impairment.
Renal_impairment
No dose adjustment is required for patients with renal impairment.
How to Take
Take orally, preferably in the morning before food. Swallow the capsule whole with water; do not chew, crush, or open the capsule.
Mechanism of Action
Irreversibly blocks the H+/K+-ATPase proton pump in gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Acid secretion inhibition begins within 1 hour, with maximal effect seen within 4 days of therapy.
Excretion
Mainly excreted via urine (approx. 80%) and feces (approx. 20%) as metabolites.
Half life
Plasma half-life is approximately 0.5-1 hour.
Absorption
Rapidly absorbed from the gastrointestinal tract. Bioavailability is approximately 30-40%.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin.
Diazepam
Delayed elimination of diazepam.
Warfarin
Increased INR and prothrombin time, increasing risk of bleeding.
Clopidogrel
Reduced antiplatelet effect, potentially increasing risk of cardiovascular events.
Methotrexate
Increased and prolonged serum levels of methotrexate.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Exercise caution during lactation, as omeprazole is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin.
Diazepam
Delayed elimination of diazepam.
Warfarin
Increased INR and prothrombin time, increasing risk of bleeding.
Clopidogrel
Reduced antiplatelet effect, potentially increasing risk of cardiovascular events.
Methotrexate
Increased and prolonged serum levels of methotrexate.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Exercise caution during lactation, as omeprazole is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Omeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in various acid-related disorders.
Lab Monitoring
- Serum magnesium levels (especially with prolonged use or concomitant digoxin/diuretics)
- Vitamin B12 levels (with long-term therapy)
- Bone density (with very long-term use)
Doctor Notes
- Consider the lowest effective dose for the shortest duration necessary for the condition.
- Monitor patients on long-term therapy for potential adverse effects such as bone fractures, C. difficile infections, and vitamin B12 deficiency.
- Counsel patients on proper administration (take before food, do not crush/chew) and lifestyle modifications.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine or change your dose without consulting your doctor.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Omeprazole may cause dizziness or visual disturbances in some individuals. Patients should be advised not to drive or operate machinery if they experience these effects.
Lifestyle Advice
- Avoid fatty, spicy, and acidic foods that can trigger heartburn.
- Reduce or eliminate alcohol and smoking, as they can exacerbate acid reflux.
- Eat smaller, more frequent meals and avoid lying down immediately after eating.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.