p-cool
Generic Name
Methyl Salicylate and Menthol Cream
Manufacturer
A Pharmaceutical Company Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| p cool 15 10 cream | ৳ 27.00 | N/A |
Description
Overview of the medicine
p-cool-15-10-cream is a topical analgesic cream containing methyl salicylate and menthol. It is used to relieve pain in muscles, joints, and tendons.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area 3-4 times daily, or as directed by a physician.
Elderly
No specific dose adjustment required, apply as for adults.
Renal_impairment
Use with caution in severe renal impairment due to systemic absorption of salicylates.
How to Take
For external use only. Wash hands before and after application. Do not apply to open wounds, damaged skin, or mucous membranes. Avoid contact with eyes.
Mechanism of Action
Methyl Salicylate is a topical NSAID that inhibits prostaglandin synthesis, providing anti-inflammatory and analgesic effects. Menthol acts as a counterirritant, producing a cooling sensation that distracts from pain.
Pharmacokinetics
Onset
Within minutes for menthol's cooling effect, 15-30 minutes for analgesic effects.
Excretion
Metabolites of both are primarily excreted in urine.
Half life
Salicylic acid (from methyl salicylate) has a half-life of 2-4 hours, menthol's is shorter.
Absorption
Both methyl salicylate and menthol are absorbed percutaneously. Absorption rate can vary with skin integrity, area of application, and occlusion.
Metabolism
Methyl salicylate is hydrolyzed to salicylic acid primarily in the liver. Menthol is metabolized in the liver via glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to salicylates (e.g., aspirin) or any component of the cream
- Children under 2 years of age
- Application to broken or irritated skin
- Asthma or nasal polyps (due to salicylate cross-reactivity)
Drug Interactions
Other NSAIDs
Concurrent use of other NSAIDs, especially systemic ones, may increase the risk of adverse effects.
Oral Anticoagulants (e.g., Warfarin)
Topical salicylates can be absorbed systemically and may potentiate the effects of oral anticoagulants, increasing bleeding risk.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Systemic toxicity from topical overdose is rare but possible with large area application or damaged skin. Symptoms include nausea, vomiting, tinnitus, dizziness, and hyperventilation. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use with caution during pregnancy, especially in the third trimester, due to potential salicylate effects on the fetus (e.g., premature ductus arteriosus closure). Consult a physician. Limited data on excretion into breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to salicylates (e.g., aspirin) or any component of the cream
- Children under 2 years of age
- Application to broken or irritated skin
- Asthma or nasal polyps (due to salicylate cross-reactivity)
Drug Interactions
Other NSAIDs
Concurrent use of other NSAIDs, especially systemic ones, may increase the risk of adverse effects.
Oral Anticoagulants (e.g., Warfarin)
Topical salicylates can be absorbed systemically and may potentiate the effects of oral anticoagulants, increasing bleeding risk.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Systemic toxicity from topical overdose is rare but possible with large area application or damaged skin. Symptoms include nausea, vomiting, tinnitus, dizziness, and hyperventilation. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use with caution during pregnancy, especially in the third trimester, due to potential salicylate effects on the fetus (e.g., premature ductus arteriosus closure). Consult a physician. Limited data on excretion into breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Expired / Generic available
Clinical Trials
Studies support the efficacy of methyl salicylate and menthol in topical pain relief. No specific large-scale trials for 'p-cool' are publicly available, but general data on similar formulations exist.
Lab Monitoring
- Generally not required for typical topical use. In cases of extensive use or suspected systemic absorption, salicylate levels may be monitored.
Doctor Notes
- Counsel patients on proper application technique and warning signs of systemic absorption.
- Advise against use on compromised skin or under occlusive dressings.
- Emphasize avoiding contact with eyes and mucous membranes.
Patient Guidelines
- Do not use on children under 2 years unless directed by a doctor.
- Wash hands thoroughly after applying.
- Avoid contact with eyes and mucous membranes.
- Do not bandage the treated area tightly.
Missed Dose Advice
Apply the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. Do not apply extra cream to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Consider rest for the affected area.
- Consult a doctor if pain persists for more than 7 days or worsens.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.