Palorex
Generic Name
Palozepam
Manufacturer
Reputable Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| palorex 05 mg tablet | ৳ 23.00 | ৳ 230.00 |
Description
Overview of the medicine
Palorex 0.5 mg Tablet contains Palozepam, a benzodiazepine derivative primarily used for its anxiolytic, hypnotic, and muscle relaxant properties. It is prescribed for the short-term management of anxiety and insomnia.
Uses & Indications
Dosage
Adults
Anxiety: 0.5 mg 2-3 times daily. Insomnia: 0.5-1 mg at bedtime.
Elderly
Initial dose of 0.25 mg once or twice daily, gradually increasing if necessary.
Renal_impairment
Use with caution. Dosage reduction may be necessary.
How to Take
Administer orally with or without food. Do not crush or chew the tablet.
Mechanism of Action
Palozepam enhances the effect of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system, by binding to GABA-A receptors. This leads to reduced neuronal excitability, resulting in anxiolytic, sedative, hypnotic, anticonvulsant, and muscle relaxant effects.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted via the kidneys as glucuronide conjugates of metabolites.
Half life
Approximately 10-20 hours
Absorption
Rapidly and completely absorbed from the gastrointestinal tract after oral administration.
Metabolism
Extensively metabolized in the liver, primarily via CYP3A4 and CYP2C19 enzymes, into active and inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Palozepam or other benzodiazepines.
- •Acute narrow-angle glaucoma.
- •Severe respiratory insufficiency.
- •Sleep apnea syndrome.
- •Myasthenia gravis.
Drug Interactions
Opioids
Increased risk of respiratory depression and sedation.
Alcohol & CNS Depressants
Potentiates CNS depressant effects.
CYP3A4 inhibitors (e.g., Ketoconazole)
May increase Palozepam levels.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, diminished reflexes, coma, and cardiorespiratory depression. Treatment is primarily supportive. Flumazenil may be used as an antidote.
Pregnancy & Lactation
Category D. Avoid during pregnancy due to risk of congenital malformations and withdrawal symptoms in neonates. Excreted in breast milk, so avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by local regulatory authority (e.g., DGDA)
Patent Status
Patent expired
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Global Brand Names
International brand names for this medicine
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