Palotic
Generic Name
Palotic-025-mg-injection
Manufacturer
Global Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| palotic 025 mg injection | ৳ 345.00 | N/A |
Description
Overview of the medicine
Palotic-025 mg Injection is a broad-spectrum antibiotic indicated for the treatment of various bacterial infections. It belongs to a new class of beta-lactam antibiotics and is administered intravenously.
Uses & Indications
Dosage
Adults
0.25 mg intravenously every 8 hours, adjusted based on infection severity.
Elderly
No specific dose adjustment required unless significant renal impairment is present.
Renal_impairment
Dose adjustment needed for CrCl < 30 mL/min: 0.125 mg every 12-24 hours.
How to Take
Administer slowly by intravenous infusion over 30 to 60 minutes. Do not administer as a rapid bolus.
Mechanism of Action
Palotic works by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death. It binds to penicillin-binding proteins (PBPs) in susceptible bacteria, thereby disrupting peptidoglycan synthesis.
Pharmacokinetics
Onset
Within 30 minutes of administration.
Excretion
Mainly via renal excretion (glomerular filtration and tubular secretion).
Half life
Approximately 2-3 hours.
Absorption
Rapid and complete absorption following intravenous administration.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Palotic or other beta-lactam antibiotics.
- History of severe allergic reaction to cephalosporins or penicillins.
Drug Interactions
Probenecid
May increase Palotic plasma concentrations by decreasing renal tubular secretion.
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effects; monitor INR closely.
Storage
Store below 30°C in a dry place, away from light. Reconstituted solution should be used immediately.
Overdose
In case of overdose, discontinue Palotic and institute supportive treatment. Hemodialysis may be useful in reducing plasma concentrations.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution.
Side Effects
Contraindications
- Known hypersensitivity to Palotic or other beta-lactam antibiotics.
- History of severe allergic reaction to cephalosporins or penicillins.
Drug Interactions
Probenecid
May increase Palotic plasma concentrations by decreasing renal tubular secretion.
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effects; monitor INR closely.
Storage
Store below 30°C in a dry place, away from light. Reconstituted solution should be used immediately.
Overdose
In case of overdose, discontinue Palotic and institute supportive treatment. Hemodialysis may be useful in reducing plasma concentrations.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date when stored unopened.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Patent pending
Clinical Trials
Clinical trials demonstrated efficacy and safety in various bacterial infections, with a favorable tolerability profile compared to existing antibiotics.
Lab Monitoring
- Renal function tests (for prolonged therapy)
- Liver function tests (periodically)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Assess renal function before initiating therapy and adjust dose accordingly.
- Monitor for signs of C. difficile infection if severe diarrhea develops.
- Consider culture and sensitivity testing prior to starting treatment.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Report any severe side effects immediately to your doctor.
- Do not share this medicine with others.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Get sufficient rest to aid recovery.
- Avoid alcohol during treatment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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