Panfast
Generic Name
Pantoprazole Sodium Sesquihydrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| panfast 40 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Panfast 40 mg Injection contains Pantoprazole, a proton pump inhibitor used to reduce stomach acid production. It is prescribed for conditions like gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome, especially when oral administration is not possible.
Uses & Indications
Dosage
Adults
Typically 40 mg once daily by intravenous infusion over 2-15 minutes, or as a continuous infusion. Duration of IV therapy should be as short as possible, usually 7-10 days, then switch to oral therapy.
Elderly
No dosage adjustment is generally necessary, but caution is advised due to potential for reduced hepatic function.
Renal_impairment
No dosage adjustment is required for patients with renal impairment or undergoing hemodialysis.
How to Take
Administer intravenously as a slow infusion over 2 to 15 minutes, or as a continuous infusion. The solution should be prepared by dissolving the powder in the provided solvent and further diluting if necessary.
Mechanism of Action
Pantoprazole irreversibly binds to and inhibits the H+/K+-ATPase (proton pump) in the secretory canaliculi of gastric parietal cells, thereby suppressing the final step in gastric acid secretion.
Pharmacokinetics
Onset
Acid suppression begins within 15-30 minutes.
Excretion
Mainly excreted renally (approx. 80%) and the remainder in feces via biliary excretion.
Half life
Approximately 1 hour (terminal half-life), but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after intravenous administration. Bioavailability is 100% via IV route.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 (CYP) enzymes, mainly CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Patients with severe hepatic impairment for long-term use (consult physician).
Drug Interactions
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel by inhibiting its conversion to active metabolite. Concomitant use should be approached with caution.
Methotrexate
May increase and prolong serum levels of methotrexate and/or its metabolite, particularly with high doses of methotrexate. Consider temporary withdrawal of PPI.
Atazanavir, Nelfinavir
Concomitant use with PPIs is not recommended due to significantly reduced plasma concentrations of antiretroviral drugs, potentially leading to loss of therapeutic effect and development of resistance.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Reconstituted solution is stable for a limited time (e.g., 24 hours at room temperature).
Overdose
In case of overdose, seek immediate medical attention. Management is symptomatic and supportive. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Pantoprazole is excreted into breast milk; caution is advised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Patients with severe hepatic impairment for long-term use (consult physician).
Drug Interactions
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel by inhibiting its conversion to active metabolite. Concomitant use should be approached with caution.
Methotrexate
May increase and prolong serum levels of methotrexate and/or its metabolite, particularly with high doses of methotrexate. Consider temporary withdrawal of PPI.
Atazanavir, Nelfinavir
Concomitant use with PPIs is not recommended due to significantly reduced plasma concentrations of antiretroviral drugs, potentially leading to loss of therapeutic effect and development of resistance.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Reconstituted solution is stable for a limited time (e.g., 24 hours at room temperature).
Overdose
In case of overdose, seek immediate medical attention. Management is symptomatic and supportive. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Pantoprazole is excreted into breast milk; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (refer to package for exact expiry date)
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Pantoprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Ongoing research continues to explore its long-term effects and new indications.
Lab Monitoring
- Monitor serum magnesium levels periodically, especially in patients on prolonged therapy or concomitant with other magnesium-lowering drugs.
- Monitor liver function tests in patients with hepatic impairment.
Doctor Notes
- Ensure correct intravenous administration technique.
- Monitor patients for potential long-term risks with extended PPI therapy.
- Consider switching to oral PPI once oral intake is feasible.
Patient Guidelines
- Follow your doctor's instructions regarding the dose and duration of treatment.
- Report any unusual or severe side effects to your doctor immediately.
- Do not stop the medication suddenly without consulting your doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or visual disturbances in some individuals. If you experience such effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods that trigger heartburn or acid reflux, such as spicy foods, fatty foods, and citrus.
- Maintain a healthy weight and avoid smoking and excessive alcohol consumption.
- Eat smaller, more frequent meals and avoid lying down immediately after eating.
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