Para
Generic Name
Paracetamol 500 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| para 500 mg tablet | ৳ 1.20 | N/A |
Description
Overview of the medicine
Paracetamol 500 mg tablet is a commonly used medication for pain relief and fever reduction. It belongs to a class of drugs called analgesics and antipyretics.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg every 4-6 hours as needed. Maximum 4000 mg in 24 hours.
Elderly
Same as adults, but may require lower doses in debilitated or renally impaired elderly patients.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment (CrCl < 10 mL/min). Interval extension to 6-8 hours.
How to Take
Oral administration with or without food. Swallow the tablet whole with water.
Mechanism of Action
Paracetamol's exact mechanism is not fully understood but is thought to involve inhibition of prostaglandin synthesis, primarily in the central nervous system (CNS), reducing pain and fever. It has weak anti-inflammatory effects.
Pharmacokinetics
Onset
30-60 minutes (analgesia), 30 minutes (antipyresis)
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates.
Half life
1-4 hours (typically 2-3 hours)
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 to a toxic metabolite (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- •Hypersensitivity to paracetamol
- •Severe hepatic impairment
Drug Interactions
Alcohol
Increases risk of hepatotoxicity, especially with chronic heavy use.
Warfarin
May enhance anticoagulant effect, increasing risk of bleeding.
Cholestyramine
May decrease paracetamol absorption.
Metoclopramide, Domperidone
May increase paracetamol absorption.
Phenobarbital, Phenytoin, Carbamazepine
May increase risk of hepatotoxicity due to enzyme induction.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture.
Overdose
Symptoms include nausea, vomiting, abdominal pain, pallor, and sweating. Severe overdose can lead to hepatic necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC).
Pregnancy & Lactation
Generally considered safe for use during all stages of pregnancy and lactation when used at recommended doses. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 3-5 years from manufacturing date.
Availability
Pharmacies, supermarkets
Approval Status
Widely approved globally for decades
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in