Administered as a slow intravenous infusion. Initial infusion rate should be slow (e.g., 0.4 ml/kg/h) and, if well tolerated, can be gradually increased. Do not administer intramuscularly or subcutaneously.

Pentaglobin provides passive immunity by supplying a broad spectrum of antibodies (IgG, IgA, and notably IgM) against various pathogens. The IgM component is particularly important for its potent bactericidal and opsonizing activity, neutralization of bacterial toxins, and activation of the complement system, which are crucial in the early stages of severe infections.

• •Known hypersensitivity to human immunoglobulins or any excipients.
• •Patients with severe IgA deficiency who have antibodies against IgA (rare, but a risk for IVIg products).

Store between 2°C and 8°C (refrigerate). Do not freeze. Protect from light. Do not use after the expiry date.

Overdose is rarely reported. High doses may lead to hyperviscosity, fluid overload, and potential renal dysfunction. Management should be symptomatic and supportive, including monitoring fluid balance and renal function.

Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Immunoglobulins are generally considered safe as they are endogenous substances, but caution is advised and a physician should be consulted.