Perigut
Generic Name
prucalopride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Perigut (Prucalopride) is a medication used to treat chronic idiopathic constipation in adults for whom laxatives do not provide adequate relief.
Uses & Indications
Dosage
Adults
2 mg once daily. In some cases, 1 mg once daily may be sufficient.
Elderly
Initially 1 mg once daily; increase to 2 mg if needed and tolerated.
Renal_impairment
Severe renal impairment (CrCl < 30 mL/min): 1 mg once daily. No dosage adjustment needed for mild to moderate impairment.
How to Take
Taken orally with or without food, preferably at the same time each day.
Mechanism of Action
Prucalopride is a selective, high-affinity 5-HT4 receptor agonist that stimulates colonic motility, leading to increased bowel movements and improved stool consistency.
Pharmacokinetics
Onset
Typically within 2-3 days of starting treatment.
Excretion
Primarily via urine (approximately 60% unchanged drug) and feces.
Half life
Approximately 24-28 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 2-3 hours.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to prucalopride or any excipient
- Intestinal perforation or obstruction
- Inflammatory bowel disease (Crohn's disease, ulcerative colitis)
- Toxic megacolon/megarectum
Drug Interactions
Erythromycin
May slightly increase prucalopride plasma levels.
Ketoconazole
May increase prucalopride plasma levels, though generally not clinically significant.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data on overdose. Symptoms may include headache, nausea, and diarrhea. Management should be symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy due to limited data; use only if clearly necessary and potential benefits outweigh risks. Caution advised during lactation as prucalopride is excreted into breast milk.
Side Effects
Contraindications
- Hypersensitivity to prucalopride or any excipient
- Intestinal perforation or obstruction
- Inflammatory bowel disease (Crohn's disease, ulcerative colitis)
- Toxic megacolon/megarectum
Drug Interactions
Erythromycin
May slightly increase prucalopride plasma levels.
Ketoconazole
May increase prucalopride plasma levels, though generally not clinically significant.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data on overdose. Symptoms may include headache, nausea, and diarrhea. Management should be symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy due to limited data; use only if clearly necessary and potential benefits outweigh risks. Caution advised during lactation as prucalopride is excreted into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, EMA, DGDA)
Patent Status
Off-patent in many regions
Clinical Trials
Extensive clinical trials have demonstrated prucalopride's efficacy and safety in treating chronic idiopathic constipation. Key studies include PRU-USA-3, PRU-USA-4, and PRU-USA-13.
Lab Monitoring
- No specific routine lab monitoring required.
Doctor Notes
- Ensure diagnosis of chronic idiopathic constipation is confirmed before prescribing.
- Assess renal function before initiating treatment, especially in elderly patients.
- Monitor for new or worsening psychiatric symptoms, though rare.
Patient Guidelines
- Take as prescribed, do not exceed recommended dose.
- Inform your doctor if you experience severe diarrhea or abdominal pain.
- Drink plenty of fluids while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Perigut may cause dizziness and fatigue. Patients should be advised not to drive or operate machinery if they experience these symptoms.
Lifestyle Advice
- Maintain a high-fiber diet.
- Engage in regular physical activity.
- Ensure adequate hydration.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.