Permenin Forte
Generic Name
permenin
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Permenin is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
200 mg to 400 mg every 4-6 hours as needed, maximum 1200 mg/day.
Elderly
Start with the lowest effective dose and monitor for adverse effects.
Renal_impairment
Use with caution; dose reduction may be necessary.
How to Take
Oral, preferably with food or milk to minimize gastrointestinal discomfort.
Mechanism of Action
Permenin inhibits the cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins, mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief within 30 minutes.
Excretion
Excreted mainly in the urine as metabolites and their conjugates, with a small amount excreted in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via oxidation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to permenin or other NSAIDs
- History of gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase lithium plasma levels.
Warfarin
May increase the risk of bleeding.
ACE inhibitors/Diuretics
May reduce their antihypertensive effects and increase the risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, drowsiness. Management involves symptomatic and supportive care; gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Contraindicated in the third trimester of pregnancy due to potential fetal harm. Use with caution during lactation; consult a physician.
Side Effects
Contraindications
- Hypersensitivity to permenin or other NSAIDs
- History of gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase lithium plasma levels.
Warfarin
May increase the risk of bleeding.
ACE inhibitors/Diuretics
May reduce their antihypertensive effects and increase the risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, drowsiness. Management involves symptomatic and supportive care; gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Contraindicated in the third trimester of pregnancy due to potential fetal harm. Use with caution during lactation; consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent expired
Clinical Trials
Clinical trials have demonstrated Permenin's efficacy in reducing pain and inflammation comparable to other NSAIDs, with a well-established safety profile when used as directed.
Lab Monitoring
- Monitor renal function (creatinine, GFR) in patients on long-term therapy or with pre-existing renal impairment.
- Monitor liver function tests periodically.
- Complete blood count (CBC) to check for anemia in long-term users.
Doctor Notes
- Advise patients to report any signs of GI bleeding or cardiovascular symptoms immediately.
- Consider lowest effective dose for shortest duration, especially in elderly or those with comorbidities.
Patient Guidelines
- Take with food or after meals to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Seek medical attention if you experience severe abdominal pain, black stools, or unusual bleeding.
Missed Dose Advice
If a dose is missed, take it as soon as remembered unless it's almost time for the next dose. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; use caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.