Phendrin Plus
Generic Name
phendrin
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Phendrin is a sympathomimetic agent primarily used for its vasoconstrictive and bronchodilatory effects. It acts by stimulating alpha and beta adrenergic receptors, leading to various physiological responses.
Uses & Indications
Dosage
Adults
Oral, 25 mg every 4-6 hours as needed. Maximum 150 mg per day.
Elderly
A reduced dose may be required, consult a physician.
Renal_impairment
Use with caution; dose adjustment may be necessary based on renal function.
How to Take
Take orally with a glass of water, with or without food. Do not crush or chew extended-release formulations.
Mechanism of Action
Phendrin acts as an indirect sympathomimetic by causing the release of norepinephrine from presynaptic nerve terminals. It also has direct agonistic effects on alpha and beta adrenergic receptors, leading to vasoconstriction, bronchodilation, and CNS stimulation.
Pharmacokinetics
Onset
Within 30-60 minutes after oral administration.
Excretion
Excreted mainly via the kidneys, partially unchanged.
Half life
Approximately 3-6 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to phendrin or any component
- Severe hypertension
- Coronary artery disease
- Angle-closure glaucoma
- Concomitant use with MAO inhibitors
Drug Interactions
Beta-blockers
May reduce the bronchodilatory effects and increase risk of hypertension.
MAO Inhibitors
Increased risk of hypertensive crisis.
Digitalis Glycosides
Increased risk of cardiac arrhythmias.
Tricyclic Antidepressants (TCAs)
May potentiate the pressor effects of phendrin.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms may include severe hypertension, tachycardia, palpitations, agitation, seizures, and respiratory depression. Treatment is supportive, including managing blood pressure and respiratory function.
Pregnancy & Lactation
Use only if clearly needed. Consult a physician before use during pregnancy or lactation. Limited data available.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved
Patent Status
Patent expired
Clinical Trials
Several Phase III clinical trials demonstrated efficacy in reducing nasal congestion with an acceptable safety profile. Further studies are ongoing for other indications.
Lab Monitoring
- Monitor blood pressure regularly, especially in patients with pre-existing hypertension.
- Monitor heart rate.
Doctor Notes
- Advise patients to monitor blood pressure regularly, especially if they have pre-existing cardiovascular conditions.
- Caution patients about potential CNS stimulatory effects, especially at night.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking close to bedtime to prevent insomnia.
- Report any severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a balanced diet and regular exercise.
- Limit intake of stimulants like coffee, tea, and energy drinks.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.