PhenoGel
Generic Name
phenoson
Manufacturer
MediLife Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Phenoson is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins.
Uses & Indications
Dosage
Adults
Oral: 250-500 mg every 4-6 hours as needed. Maximum 2000 mg per day.
Elderly
Lower doses may be required due to increased sensitivity and potential for renal impairment. Start with 250 mg every 6-8 hours.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with moderate to severe renal impairment (CrCl < 30 mL/min). Avoid in severe renal failure.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Do not crush or chew the tablet.
Mechanism of Action
Phenoson primarily acts by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This inhibition leads to a reduced synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief typically begins within 30-60 minutes.
Excretion
Excreted mainly through the kidneys (approximately 60% as metabolites and less than 1% as unchanged drug), with a small amount excreted in feces.
Half life
Elimination half-life ranges from 2 to 4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1-2 hours after oral administration. Bioavailability is high.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (e.g., CYP2C9 and CYP2C19) into inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to phenoson or other NSAIDs (e.g., aspirin-induced asthma)
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate toxicity.
Other NSAIDs and Aspirin
Increased risk of gastrointestinal side effects.
Diuretics and ACE inhibitors
May reduce their antihypertensive effects and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, renal failure, hypotension, respiratory depression, and coma may occur. Management is primarily symptomatic and supportive, including gastric lavage or activated charcoal if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C (first and second trimester), Category D (third trimester). Avoid phenoson during the third trimester of pregnancy due to potential fetal cardiovascular effects. Consult a doctor before use during lactation; a small amount may pass into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to phenoson or other NSAIDs (e.g., aspirin-induced asthma)
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate toxicity.
Other NSAIDs and Aspirin
Increased risk of gastrointestinal side effects.
Diuretics and ACE inhibitors
May reduce their antihypertensive effects and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, renal failure, hypotension, respiratory depression, and coma may occur. Management is primarily symptomatic and supportive, including gastric lavage or activated charcoal if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C (first and second trimester), Category D (third trimester). Avoid phenoson during the third trimester of pregnancy due to potential fetal cardiovascular effects. Consult a doctor before use during lactation; a small amount may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Expired
Clinical Trials
Phase III clinical trials demonstrated efficacy in pain and inflammation reduction comparable to existing NSAIDs, with a favorable safety profile for short-term use.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) periodically, especially in long-term therapy or in patients with risk factors.
- Liver function tests (e.g., ALT, AST) if long-term use or symptoms of hepatic dysfunction occur.
- Complete blood count (CBC) if long-term use is anticipated.
Doctor Notes
- Advise patients on the lowest effective dose for the shortest duration necessary.
- Exercise caution in elderly patients, those with a history of GI disease, cardiovascular risk factors, or renal impairment.
- Monitor for signs of GI bleeding, cardiovascular events, and renal dysfunction.
Patient Guidelines
- Take phenoson exactly as prescribed by your doctor.
- Always take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose or duration of use.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Phenoson may cause dizziness or drowsiness in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking phenoson, as it may increase the risk of stomach bleeding.
- Maintain adequate hydration, especially in warm weather or during exercise.
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