Picorif
Generic Name
Sodium Picosulfate
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| picorif 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Picorif 10 mg Tablet contains Sodium Picosulfate, a stimulant laxative used for the short-term treatment of constipation and for bowel preparation before medical procedures.
Uses & Indications
Dosage
Adults
10-20 mg (1-2 tablets) once daily at night. Adjust dose according to individual response.
Elderly
Start with the lowest effective dose (e.g., 5 mg) and adjust as needed.
Renal_impairment
No specific dose adjustment required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Swallow the tablet whole with water, preferably at night to produce a bowel movement the next morning.
Mechanism of Action
Sodium Picosulfate is a prodrug that is converted by colonic bacteria into its active metabolite, bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM). BHPM acts directly on the colonic mucosa, stimulating peristalsis and promoting fluid and electrolyte accumulation in the colon, leading to increased stool bulk and easier passage.
Pharmacokinetics
Onset
6-12 hours
Excretion
Mainly excreted via feces as active metabolite; some urinary excretion of conjugated metabolites.
Half life
Not clearly defined for the prodrug, active metabolite has a short half-life.
Absorption
Minimal absorption from the gastrointestinal tract; primarily converted by colonic bacteria.
Metabolism
Converted to active metabolite (BHPM) by colonic bacteria; subsequent hepatic conjugation and enterohepatic recirculation for a small fraction.
Side Effects
Contraindications
- Hypersensitivity to sodium picosulfate or any component of the tablet
- Acute surgical abdomen, severe abdominal pain with nausea and vomiting, intestinal obstruction, inflammatory bowel disease, severe dehydration
Drug Interactions
Antibiotics (broad-spectrum)
May reduce laxative effect by altering colonic flora responsible for prodrug conversion.
Diuretics, Adrenocorticosteroids
May increase electrolyte imbalance, especially hypokalemia.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe abdominal cramps, fluid and electrolyte disturbances (especially hypokalemia), and severe diarrhea. Management involves supportive care, correction of fluid and electrolyte imbalances.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Limited data available on use during lactation; caution advised.
Side Effects
Contraindications
- Hypersensitivity to sodium picosulfate or any component of the tablet
- Acute surgical abdomen, severe abdominal pain with nausea and vomiting, intestinal obstruction, inflammatory bowel disease, severe dehydration
Drug Interactions
Antibiotics (broad-spectrum)
May reduce laxative effect by altering colonic flora responsible for prodrug conversion.
Diuretics, Adrenocorticosteroids
May increase electrolyte imbalance, especially hypokalemia.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe abdominal cramps, fluid and electrolyte disturbances (especially hypokalemia), and severe diarrhea. Management involves supportive care, correction of fluid and electrolyte imbalances.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Limited data available on use during lactation; caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, supermarkets
Approval Status
Approved by regulatory authorities
Patent Status
Generic
Clinical Trials
Sodium Picosulfate has been extensively studied for its efficacy and safety in various clinical trials for constipation and bowel preparation.
Lab Monitoring
- Monitoring of electrolytes (especially potassium) may be advisable in patients on long-term therapy or with pre-existing conditions.
Doctor Notes
- Advise patients on the short-term use and potential for electrolyte imbalance with prolonged use.
- Consider underlying causes of constipation before prescribing, and recommend lifestyle modifications.
Patient Guidelines
- Do not use for more than 7 consecutive days without consulting a doctor.
- Drink plenty of fluids to prevent dehydration.
- Report severe or persistent abdominal pain, rectal bleeding, or failure to have a bowel movement.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
Generally safe, but if dizziness occurs, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a high-fiber diet.
- Engage in regular physical activity.
- Ensure adequate fluid intake.
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Global Brand Names
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