Pivasta
Generic Name
Pitavastatin 2 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pivasta 2 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Pivasta 2 mg tablet contains Pitavastatin, a statin used to lower high cholesterol levels and reduce the risk of cardiovascular diseases. It works by reducing the production of cholesterol in the liver.
Uses & Indications
Dosage
Adults
Initial dose 1 mg once daily, usually adjusted to 2-4 mg once daily based on LDL-C levels. Maximum 4 mg once daily.
Elderly
No specific dose adjustment required, but caution is advised.
Renal_impairment
Initial dose 1 mg once daily for moderate to severe impairment (CrCl < 60 mL/min). Maximum 2 mg once daily.
How to Take
Take orally once daily, with or without food, preferably at the same time each day. Can be taken in the morning or evening.
Mechanism of Action
Pitavastatin competitively inhibits HMG-CoA reductase, an enzyme that catalyzes the early, rate-limiting step in cholesterol biosynthesis. This leads to a compensatory increase in LDL receptors on hepatocytes, increasing LDL catabolism.
Pharmacokinetics
Onset
Lipid-lowering effects typically observed within 2 weeks, maximal effect usually within 4 weeks.
Excretion
Primarily excreted via bile (feces) as unchanged drug and metabolites. Renal excretion is minor (approximately 15%).
Half life
Approximately 12 hours (terminal half-life).
Absorption
Rapidly absorbed from the gastrointestinal tract; absolute bioavailability is 51%. Peak plasma concentrations achieved within 1 hour.
Metabolism
Primarily metabolized by CYP2C8 and to a lesser extent CYP2C9; not significantly metabolized by CYP3A4.
Side Effects
Contraindications
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Pregnancy
- Lactation
- Hypersensitivity to pitavastatin or any component of the formulation
- Concomitant use with cyclosporine
Drug Interactions
Niacin
Increased risk of muscle side effects; monitor closely.
Rifampin
Increases pitavastatin exposure; caution advised.
Gemfibrozil
Increased risk of myopathy/rhabdomyolysis; concomitant use should be avoided.
Cyclosporine
Significantly increases pitavastatin exposure; concomitant use is contraindicated.
Erythromycin
Increases pitavastatin exposure; caution advised.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, supportive measures and symptomatic treatment should be initiated. Monitor liver function and CK levels. Hemodialysis is unlikely to be beneficial.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential harm to the fetus or infant. Women of childbearing potential should use effective contraception.
Side Effects
Contraindications
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Pregnancy
- Lactation
- Hypersensitivity to pitavastatin or any component of the formulation
- Concomitant use with cyclosporine
Drug Interactions
Niacin
Increased risk of muscle side effects; monitor closely.
Rifampin
Increases pitavastatin exposure; caution advised.
Gemfibrozil
Increased risk of myopathy/rhabdomyolysis; concomitant use should be avoided.
Cyclosporine
Significantly increases pitavastatin exposure; concomitant use is contraindicated.
Erythromycin
Increases pitavastatin exposure; caution advised.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, supportive measures and symptomatic treatment should be initiated. Monitor liver function and CK levels. Hemodialysis is unlikely to be beneficial.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential harm to the fetus or infant. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Patent expired, generics available
Clinical Trials
Clinical trials have demonstrated Pitavastatin's efficacy in reducing LDL-C and its favorable safety profile, including studies like the LIVES study and the PATIENT study.
Lab Monitoring
- Liver function tests (ALT, AST) before initiation and as clinically indicated
- Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) to assess response
- Creatine kinase (CK) levels if muscle symptoms develop
Doctor Notes
- Emphasize the importance of lifestyle modifications alongside medication.
- Regular monitoring of lipid profile and LFTs is crucial.
- Counsel patients on muscle pain symptoms and when to report them.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking without consulting your doctor.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Pitavastatin is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid driving.
Lifestyle Advice
- Maintain a low-fat, low-cholesterol diet.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.