Podoxi
Generic Name
Cefpodoxime Proxetil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| podoxi 40 mg suspension | ৳ 98.00 | N/A |
Description
Overview of the medicine
Podoxi (Cefpodoxime Proxetil) is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, skin infections, and sexually transmitted diseases.
Uses & Indications
Dosage
Adults
Acute exacerbations of chronic bronchitis: 200 mg every 12 hours for 10 days. Community-acquired pneumonia: 200 mg every 12 hours for 14 days. Pharyngitis/tonsillitis: 100 mg every 12 hours for 5-10 days. Uncomplicated UTI: 100 mg every 12 hours for 7 days.
Elderly
No specific dose adjustment required unless renal function is impaired.
Renal_impairment
Creatinine clearance 30-39 mL/min: Administer usual dose every 24 hours. Creatinine clearance <29 mL/min: Administer usual dose every 48 hours.
How to Take
May be taken with food to enhance absorption. Take the full course of medicine as prescribed, even if symptoms improve.
Mechanism of Action
Cefpodoxime Proxetil is a prodrug that is de-esterified in vivo to Cefpodoxime. Cefpodoxime is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), which interferes with the peptidoglycan synthesis necessary for the integrity and rigidity of the bacterial cell wall, leading to cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-3 hours.
Excretion
Primarily excreted unchanged by the kidneys, about 29-38% of the dose within 12 hours.
Half life
Approximately 2.1 to 2.8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, enhanced by food. Bioavailability is about 50%.
Metabolism
Metabolized to active cefpodoxime in the intestinal wall by esterases. Minimal hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to Cefpodoxime or other cephalosporins
- History of severe allergic reactions to penicillin
Drug Interactions
Probenecid
Increases plasma concentrations of cefpodoxime by decreasing its renal excretion.
Nephrotoxic drugs (e.g., aminoglycosides)
Monitor renal function carefully if co-administered, as risk of nephrotoxicity may increase.
Antacids/H2 blockers/Proton pump inhibitors
May decrease absorption of cefpodoxime, leading to reduced efficacy. Administer cefpodoxime 2-3 hours before or after these agents.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and used within 14 days.
Overdose
Symptoms of overdose include nausea, vomiting, epigastric distress, and diarrhea. In severe cases, encephalopathy may occur. Treatment is supportive; hemodialysis may be useful in reducing plasma levels.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months, depending on formulation and storage conditions.
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in various clinical trials demonstrating efficacy against susceptible bacterial strains in indicated infections. Ongoing post-marketing surveillance.
Lab Monitoring
- Monitor renal function (creatinine, BUN) in patients with pre-existing renal impairment or during concomitant use of nephrotoxic drugs.
- Periodic monitoring of blood counts for prolonged therapy.
Doctor Notes
- Consider patient's history of hypersensitivity to beta-lactam antibiotics.
- Adjust dose in renal impairment.
- Counsel patients on completing the full course to prevent resistance.
Patient Guidelines
- Take medicine with food.
- Complete the entire prescribed course of treatment, even if you feel better.
- Do not save medicine for future infections.
- Inform your doctor if diarrhea persists or worsens.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, it does not affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hydration, especially if experiencing diarrhea.
- Avoid alcohol, as it may worsen stomach upset.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.