Polysoft 3-0 Round Body
Generic Name
polysoft-3-0-round-body-(polyglactin)
Manufacturer
Various manufacturers produce Polyglactin sutures; specific to brand 'Polysoft'
Country
Varies by specific brand manufacturer (e.g., India, China, USA)
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Description
Overview of the medicine
Polysoft 3-0 Round Body is a sterile, synthetic, absorbable surgical suture made of Polyglactin 910. It is a braided, multifilament suture, coated to ensure smooth passage through tissue and minimal tissue drag. The 'round body' needle type is designed for soft tissue approximation, particularly in tissues where minimal trauma is desired, such as fascia, muscle, and gastrointestinal tissue. It retains tensile strength for approximately 2-3 weeks and is completely absorbed by hydrolysis within 56-70 days.
Uses & Indications
Dosage
Adults
Selected by the surgeon based on tissue type, wound depth, and anticipated stress. USP 3-0 is typically used for general closure of small to medium-sized vessels, bowel, and skin.
Elderly
No specific dosage adjustment for elderly patients; selection based on tissue quality and surgical need.
Renal_impairment
No specific dosage adjustment; suture absorption is not significantly impacted by renal function.
How to Take
Administered by a qualified surgeon during a sterile surgical procedure. The suture is used to approximate tissues or ligate blood vessels as required for wound closure.
Mechanism of Action
Polyglactin 910 sutures provide temporary mechanical support to tissue edges during the wound healing process. Its absorbability is via hydrolysis, where water molecules gradually break down the polymer chains, leading to loss of tensile strength and eventual complete absorption. This controlled degradation eliminates the need for suture removal and reduces the risk of long-term foreign body reaction.
Pharmacokinetics
Onset
Provides immediate tissue approximation upon placement.
Excretion
Metabolites (glycolic and lactic acid) are primarily excreted via urine and respiration.
Half life
Not applicable in the traditional sense; tensile strength retention profile dictates functional 'half-life'.
Absorption
Absorbed by hydrolysis; mass loss occurs through non-enzymatic degradation of the polymer.
Metabolism
Broken down into glycolic and lactic acid monomers, which are then metabolized and excreted by the body.
Side Effects
Contraindications
- •Not to be used in tissues requiring long-term tensile strength support (e.g., heart valves, vascular prostheses)
- •Not recommended for use in patients with known allergies or sensitivities to Polyglactin 910 or its components.
- •Not for use in patients who are immunocompromised or have delayed wound healing due to other medical conditions.
Drug Interactions
Anticoagulants
Use with caution in patients on anticoagulants as bleeding risk may be increased during surgery.
Immunosuppressants
May impair wound healing, potentially affecting suture integrity over time.
Storage
Store at room temperature (below 25°C), in a dry place, away from direct sunlight and moisture. Do not re-sterilize.
Overdose
Not applicable for a surgical suture.
Pregnancy & Lactation
Polyglactin 910 sutures are medical devices with no systemic absorption or known reproductive toxicity, therefore considered safe for use in surgical procedures during pregnancy and lactation when clinically indicated.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 3 to 5 years from the date of manufacture when stored properly.
Availability
Hospitals, surgical supply stores, medical distributors
Approval Status
CE Marked, widely accepted globally for surgical use
Patent Status
Generic, initial patents expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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