Posac
Generic Name
Posacetin
Manufacturer
Global Biopharma Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| posac 18 mg injection | ৳ 2,000.00 | N/A |
Description
Overview of the medicine
Posac 18 mg Injection is a targeted immunomodulator designed for the treatment of certain autoimmune conditions. It contains Posacetin, a novel biologic agent that selectively modulates immune responses to reduce inflammation and disease progression.
Uses & Indications
Dosage
Adults
18 mg administered subcutaneously once every two weeks.
Elderly
No dose adjustment is required for elderly patients (≥65 years of age).
Renal_impairment
No dose adjustment is required in patients with mild to moderate renal impairment. Data in severe renal impairment are limited.
How to Take
Posac 18 mg Injection is administered via subcutaneous injection. Patients may be trained to self-administer the injection after proper instruction from a healthcare professional. Inject into the abdomen, thigh, or upper arm, rotating injection sites.
Mechanism of Action
Posacetin selectively binds to and inhibits a specific cytokine receptor (e.g., IL-6 receptor, TNF-alpha) involved in inflammatory pathways, thereby suppressing the aberrant immune response that drives autoimmune diseases.
Pharmacokinetics
Onset
Clinical improvement typically observed within 2-4 weeks of initiation.
Excretion
Metabolites are primarily eliminated via catabolic pathways.
Half life
Approximately 12-16 days, allowing for extended dosing intervals.
Absorption
Administered subcutaneously, with peak plasma concentrations reached within 2-3 days. Absolute bioavailability is approximately 80%.
Metabolism
Primarily cleared via proteolytic degradation, typical for therapeutic proteins, rather than hepatic cytochrome P450 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Posacetin or any excipients.
- Patients with active, severe infections, including localized infections.
- Concurrent use with live vaccines.
Drug Interactions
Live Vaccines
Avoid concurrent administration due to increased risk of infection.
Immunosuppressants (e.g., Methotrexate, Corticosteroids)
Use with caution; may increase the risk of infection and malignancy. Close monitoring is advised.
Storage
Store in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
No specific antidote for Posacetin overdose. In case of an overdose, closely monitor the patient for any signs or symptoms of adverse reactions and initiate appropriate symptomatic treatment.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Posacetin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to Posacetin or any excipients.
- Patients with active, severe infections, including localized infections.
- Concurrent use with live vaccines.
Drug Interactions
Live Vaccines
Avoid concurrent administration due to increased risk of infection.
Immunosuppressants (e.g., Methotrexate, Corticosteroids)
Use with caution; may increase the risk of infection and malignancy. Close monitoring is advised.
Storage
Store in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
No specific antidote for Posacetin overdose. In case of an overdose, closely monitor the patient for any signs or symptoms of adverse reactions and initiate appropriate symptomatic treatment.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Posacetin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Hospitals and specialized pharmacies
Approval Status
Approved by regulatory authorities (e.g., FDA, EMA)
Patent Status
Patented
Clinical Trials
Posac 18 mg Injection has been evaluated in multiple Phase 3 clinical trials demonstrating its efficacy and safety in patients with various autoimmune conditions. Data from these trials supported its regulatory approval.
Lab Monitoring
- Complete Blood Count (CBC) with differential before starting treatment and periodically thereafter.
- Liver function tests (LFTs) before and periodically during treatment.
- Tuberculosis (TB) screening before initiation of therapy.
Doctor Notes
- Emphasize the importance of patient education regarding injection technique and signs of infection.
- Regular monitoring of CBC, LFTs, and TB screening is crucial.
- Consider risk-benefit ratio carefully in patients with a history of recurrent infections or malignancy.
Patient Guidelines
- Read the Medication Guide before you start taking Posac 18 mg Injection and each time you get a refill.
- Inform your doctor if you develop any signs of infection (e.g., fever, cough, flu-like symptoms).
- Do not receive live vaccines while on this medication.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. Then, resume the regular dosing schedule from the last administered dose. Do not double the dose to catch up.
Driving Precautions
Posac 18 mg Injection is not expected to affect the ability to drive or operate machinery. However, if patients experience dizziness or other adverse effects that could impair their abilities, they should avoid such activities.
Lifestyle Advice
- Maintain good hygiene to reduce infection risk.
- Avoid contact with people who have active infections.
- Discuss any planned surgeries or vaccinations with your doctor.
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