Povidone-Iodine
Generic Name
povidone-iodine-10-w-solution
Manufacturer
Multiple Manufacturers
Country
Multiple Countries
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| povidone iodine 10 w solution | ৳ 120.00 | N/A |
Description
Overview of the medicine
Povidone-iodine 10% w/v solution is an antiseptic agent used to prevent and treat skin infections in minor cuts, scrapes, and burns. It is also used for pre-operative skin preparation and for general skin disinfection.
Uses & Indications
Dosage
Adults
Apply undiluted solution to the affected skin area as needed. Allow to dry. May be repeated up to several times daily.
Elderly
No specific dosage adjustment required; use as per adult dosage.
Renal_impairment
Use with caution in patients with renal impairment, especially if extensive or prolonged use is anticipated, due to potential for systemic iodine absorption.
How to Take
For external use only. Apply topically to the skin. Do not swallow. Avoid contact with eyes.
Mechanism of Action
Povidone-iodine exerts its antimicrobial action through the sustained release of free iodine. The free iodine rapidly oxidizes microbial components, leading to the death of bacteria, fungi, viruses, and protozoa. It has a broad spectrum of activity.
Pharmacokinetics
Onset
Rapid, within seconds to minutes of application.
Excretion
Mainly through the kidneys in urine, with some fecal excretion.
Half life
Systemic iodine has a half-life of approximately 1-2 days, but for topical application, systemic half-life is less relevant due to minimal absorption.
Absorption
Minimal systemic absorption occurs through intact skin. Significant absorption can occur from damaged skin (e.g., burns), mucous membranes, or large wound surfaces, potentially leading to increased serum iodide levels.
Metabolism
Absorbed iodide is metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- Patients with thyroid disorders (e.g., hyperthyroidism, goiter), especially if used extensively
- Pre-term neonates and infants under 6 months due to risk of iodine absorption
- Extensive burns (risk of systemic absorption)
Drug Interactions
Octenidine
Use with octenidine-containing antiseptics may cause transient dark discoloration.
Mercury-containing compounds
Concurrent use may form caustic mercury iodide compounds.
Hydrogen peroxide, silver sulfadiazine, taurolidine
These compounds can inactivate povidone-iodine and vice versa.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause serious systemic effects unless applied over large areas of broken skin or ingested. Ingestion or extensive absorption can lead to systemic iodine toxicity, symptoms include gastrointestinal distress, metabolic acidosis, thyroid dysfunction, and renal impairment. Management is symptomatic and supportive.
Pregnancy & Lactation
Use with caution. Although systemic absorption is minimal, extensive use during pregnancy or lactation may lead to iodine overload in the fetus/neonate and potentially affect thyroid function. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- Patients with thyroid disorders (e.g., hyperthyroidism, goiter), especially if used extensively
- Pre-term neonates and infants under 6 months due to risk of iodine absorption
- Extensive burns (risk of systemic absorption)
Drug Interactions
Octenidine
Use with octenidine-containing antiseptics may cause transient dark discoloration.
Mercury-containing compounds
Concurrent use may form caustic mercury iodide compounds.
Hydrogen peroxide, silver sulfadiazine, taurolidine
These compounds can inactivate povidone-iodine and vice versa.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause serious systemic effects unless applied over large areas of broken skin or ingested. Ingestion or extensive absorption can lead to systemic iodine toxicity, symptoms include gastrointestinal distress, metabolic acidosis, thyroid dysfunction, and renal impairment. Management is symptomatic and supportive.
Pregnancy & Lactation
Use with caution. Although systemic absorption is minimal, extensive use during pregnancy or lactation may lead to iodine overload in the fetus/neonate and potentially affect thyroid function. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Generally approved as OTC
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Povidone-iodine has been extensively studied for its broad-spectrum antimicrobial efficacy and is a well-established antiseptic with decades of clinical use.
Lab Monitoring
- Thyroid function tests (TFTs) should be monitored in patients with pre-existing thyroid conditions or in neonates/infants if extensive or prolonged use is anticipated. Renal function may be monitored in cases of suspected systemic toxicity.
Doctor Notes
- Confirm no history of iodine allergy or significant thyroid dysfunction before recommending extensive use.
- Advise patients on proper application technique and emphasize external use only.
- Consider alternative antiseptics for neonates or patients with very large burn surfaces.
Patient Guidelines
- For external use only. Do not ingest.
- Avoid contact with eyes. Rinse thoroughly with water if contact occurs.
- Do not use on large areas of broken skin or deep wounds without medical advice.
- Discontinue use and consult a doctor if irritation, redness, or swelling persists or worsens.
Missed Dose Advice
This medicine is used as needed. If you forget to apply it, do so as soon as you remember, or simply apply it at your next scheduled time if it's for regular use.
Driving Precautions
Povidone-iodine topical solution has no known effect on the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hygiene practices to prevent infections. Keep wounds clean and covered when not applying antiseptic.
- Follow your doctor's instructions for wound care and infection prevention.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.