Povimed
Generic Name
Povidone-Iodine 10% w/v Solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| povimed 10 w solution | ৳ 35.00 | N/A |
Description
Overview of the medicine
Povimed 10% w/v Solution is a broad-spectrum antiseptic primarily used for disinfection of skin, wounds, and for pre-operative skin preparation. It contains povidone-iodine, which effectively kills bacteria, viruses, fungi, and protozoa.
Uses & Indications
Dosage
Adults
Apply undiluted solution directly to the affected skin area as needed. Allow to dry. Can be used several times a day.
Elderly
No special dosage adjustment required for elderly patients.
Renal_impairment
Use with caution in patients with severe renal impairment, especially if extensive or prolonged use, due to potential systemic iodine absorption.
How to Take
For external use only. Clean the affected area, then apply a small amount of Povimed solution. Allow to air dry. Do not bandage tightly unless advised by a healthcare professional.
Mechanism of Action
Povidone-iodine releases free iodine, which acts as an oxidizing agent. It rapidly penetrates microbial cells and disrupts proteins, nucleic acids, and other cellular components, leading to cell death. It has a broad spectrum of antimicrobial activity.
Pharmacokinetics
Onset
Rapid onset, typically within seconds to minutes of application.
Excretion
Mainly renal excretion for any absorbed iodine.
Half life
Not directly relevant for topical use, as systemic levels are usually negligible. Absorbed iodine is excreted rapidly.
Absorption
Minimal systemic absorption through intact skin. Absorption may increase with extensive skin damage or prolonged use over large areas.
Metabolism
Absorbed iodine is metabolized in the body and excreted. Not significant for typical topical application.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone.
- Thyroid disorders (e.g., hyperthyroidism, goiter) due to potential iodine absorption.
- Before and after radio-iodine therapy.
- In neonates and very young infants, especially on large areas of broken skin, due to risk of systemic iodine absorption and thyroid effects.
Drug Interactions
Lithium
Avoid extensive use in patients receiving lithium therapy, as combined effects may lead to hypothyroidism.
Other antiseptics
Do not use with mercury-containing antiseptics (e.g., mercurochrome) as it may form corrosive compounds. Avoid concomitant use with other topical preparations like hydrogen peroxide, silver sulfadiazine, or octenidine as they may reduce the efficacy of povidone-iodine.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Accidental ingestion or extensive topical application over large areas for prolonged periods can lead to systemic iodine toxicity, presenting as thyroid dysfunction (hypothyroidism or hyperthyroidism), metabolic acidosis, and renal impairment. Treatment is symptomatic and supportive, including gastric lavage for ingestion and monitoring thyroid function.
Pregnancy & Lactation
Use with caution and only if clearly needed. Extensive use, especially on large areas or broken skin, may lead to significant iodine absorption, potentially affecting fetal or infant thyroid function. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone.
- Thyroid disorders (e.g., hyperthyroidism, goiter) due to potential iodine absorption.
- Before and after radio-iodine therapy.
- In neonates and very young infants, especially on large areas of broken skin, due to risk of systemic iodine absorption and thyroid effects.
Drug Interactions
Lithium
Avoid extensive use in patients receiving lithium therapy, as combined effects may lead to hypothyroidism.
Other antiseptics
Do not use with mercury-containing antiseptics (e.g., mercurochrome) as it may form corrosive compounds. Avoid concomitant use with other topical preparations like hydrogen peroxide, silver sulfadiazine, or octenidine as they may reduce the efficacy of povidone-iodine.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Accidental ingestion or extensive topical application over large areas for prolonged periods can lead to systemic iodine toxicity, presenting as thyroid dysfunction (hypothyroidism or hyperthyroidism), metabolic acidosis, and renal impairment. Treatment is symptomatic and supportive, including gastric lavage for ingestion and monitoring thyroid function.
Pregnancy & Lactation
Use with caution and only if clearly needed. Extensive use, especially on large areas or broken skin, may lead to significant iodine absorption, potentially affecting fetal or infant thyroid function. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved (Generally OTC)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Povidone-iodine has been extensively studied and is a well-established antiseptic with decades of clinical use. New trials primarily focus on specific applications or comparisons with newer agents.
Lab Monitoring
- Typically not required for routine topical use.
- For prolonged or extensive use, especially in susceptible individuals (e.g., neonates, patients with existing thyroid conditions), thyroid function tests (TSH, T3, T4) may be monitored.
Doctor Notes
- Emphasize proper application technique and only for external use.
- Advise caution in patients with pre-existing thyroid conditions, pregnant/lactating women, and neonates.
- Monitor for signs of irritation or allergic reactions.
Patient Guidelines
- For external use only. Do not swallow.
- Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
- Do not use on large areas of broken skin or deep wounds without medical advice.
- Discontinue use if irritation or allergic reaction occurs and consult a doctor.
Missed Dose Advice
As this is a topical solution applied as needed, there is no specific concern for a 'missed dose'. Apply when necessary.
Driving Precautions
Povimed 10% w/v Solution has no known effect on the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent infections.
- Keep the treated area clean and dry.
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