Prebalin CR
Generic Name
Pregabalin Extended Release 165 mg Tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prebalin cr 165 mg tablet | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
Pregabalin CR 165 mg is an extended-release tablet used to treat various neuropathic pain conditions, fibromyalgia, and as an adjunctive therapy for partial-onset seizures. The extended-release formulation allows for once-daily dosing.
Uses & Indications
Dosage
Adults
The usual starting dose is 165 mg orally once daily. May be increased to 330 mg or 495 mg once daily based on efficacy and tolerability.
Elderly
No specific dose adjustment based solely on age, but renal function should be assessed, and dose adjusted accordingly.
Renal_impairment
Dosage should be adjusted based on creatinine clearance. Lower doses are recommended for patients with impaired renal function.
How to Take
Take the tablet orally once daily with or without food. Swallow the tablet whole; do not split, crush, or chew.
Mechanism of Action
Pregabalin binds to the alpha-2-delta (α2-δ) subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This action helps to reduce nerve pain and seizure activity.
Pharmacokinetics
Onset
Pain relief may be noticed within a week, but full therapeutic effect can take several weeks.
Excretion
Primarily excreted unchanged in the urine (approximately 98% of the dose).
Half life
Approximately 6.3 hours. The CR formulation provides sustained plasma levels suitable for once-daily dosing.
Absorption
Well absorbed after oral administration, with bioavailability exceeding 90%. Peak plasma concentrations are achieved slowly with the CR formulation, typically 8-12 hours post-dose.
Metabolism
Negligible human metabolism; less than 0.1% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
CNS Depressants (e.g., opioids, benzodiazepines, ethanol)
May potentiate the sedative and respiratory depressant effects of pregabalin. Concomitant use should be with caution.
Thiazolidinedione Antidiabetic Agents (e.g., rosiglitazone, pioglitazone)
May cause peripheral edema and weight gain. Use with caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Management is supportive and may include gastric lavage if recent ingestion. Hemodialysis is effective for removing pregabalin from the plasma.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
CNS Depressants (e.g., opioids, benzodiazepines, ethanol)
May potentiate the sedative and respiratory depressant effects of pregabalin. Concomitant use should be with caution.
Thiazolidinedione Antidiabetic Agents (e.g., rosiglitazone, pioglitazone)
May cause peripheral edema and weight gain. Use with caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Management is supportive and may include gastric lavage if recent ingestion. Hemodialysis is effective for removing pregabalin from the plasma.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic versions available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of pregabalin in treating neuropathic pain, fibromyalgia, and as adjunctive therapy for partial-onset seizures. CR formulations specifically focus on improving patient compliance through once-daily dosing.
Lab Monitoring
- Renal function tests (creatinine clearance) before initiation and periodically during treatment.
- Monitor for signs of peripheral edema and weight gain.
Doctor Notes
- Counsel patients on potential CNS depressant effects and the importance of gradual discontinuation.
- Monitor renal function, especially in elderly patients and those with pre-existing renal impairment.
- Advise patients about the risk of suicidal ideation and to report any changes in mood or behavior.
Patient Guidelines
- Do not stop taking this medicine abruptly; consult your doctor for gradual dose reduction.
- Report any unusual mood changes or thoughts of self-harm to your doctor immediately.
- Avoid alcohol while taking this medicine.
- This medicine may cause dizziness and somnolence; avoid driving or operating heavy machinery until you know how it affects you.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pregabalin CR may cause dizziness, somnolence, and blurred vision. Patients should be advised not to drive or operate complex machinery until they have gained sufficient experience with pregabalin CR to gauge whether it adversely affects their ability to drive or operate machinery.
Lifestyle Advice
- Maintain a healthy diet and exercise regime.
- Manage stress effectively through relaxation techniques.
- Ensure adequate sleep.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.