Precon
Generic Name
Progesterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| precon 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Precon 50 mg Tablet contains Progesterone, a natural female hormone essential for regulating ovulation and menstruation. It's used in fertility treatments, managing gynecological conditions, and hormone replacement therapy.
Uses & Indications
Dosage
Adults
Dosage varies by indication. For luteal phase support, typically 200-400 mg daily. For recurrent/threatened miscarriage, 100-200 mg daily. For secondary amenorrhea, 50-100 mg daily for 5-10 days, followed by a withdrawal bleed. Always follow doctor's prescription.
Elderly
Use with caution. Dosage adjustment usually not required unless hepatic or renal impairment is present.
Renal_impairment
Use with caution. Dosage adjustments may be necessary; consult a physician.
How to Take
Take orally with water, preferably at bedtime to minimize potential side effects like drowsiness. Can be taken with or without food.
Mechanism of Action
Progesterone primarily acts by binding to progesterone receptors, leading to changes in gene expression. It prepares the endometrium for embryo implantation, helps maintain pregnancy, and inhibits uterine contractions.
Pharmacokinetics
Onset
Varies by indication and route of administration.
Excretion
Mainly excreted in the urine as metabolites, with a small amount in bile/faeces.
Half life
Plasma half-life of oral micronized progesterone is typically 5-20 hours.
Absorption
Well absorbed orally, but undergoes significant first-pass metabolism in the liver.
Metabolism
Primarily metabolized in the liver by reduction and conjugation.
Side Effects
Contraindications
- Hypersensitivity to progesterone or any excipients
- Undiagnosed vaginal bleeding
- Known or suspected breast or genital malignancy
- Active thrombophlebitis or thromboembolic disorders
- Severe hepatic dysfunction
- Missed abortion
Drug Interactions
Anticoagulants
Progesterone may affect the metabolism of certain anticoagulants, requiring monitoring.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin)
May decrease progesterone plasma levels, reducing its therapeutic effect.
CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole)
May increase progesterone plasma levels, potentially leading to increased side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, fatigue, and nausea. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Precon is often used during pregnancy for specific indications like threatened or recurrent miscarriage and luteal phase support, under medical supervision. Generally considered safe during lactation, but consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to progesterone or any excipients
- Undiagnosed vaginal bleeding
- Known or suspected breast or genital malignancy
- Active thrombophlebitis or thromboembolic disorders
- Severe hepatic dysfunction
- Missed abortion
Drug Interactions
Anticoagulants
Progesterone may affect the metabolism of certain anticoagulants, requiring monitoring.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin)
May decrease progesterone plasma levels, reducing its therapeutic effect.
CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole)
May increase progesterone plasma levels, potentially leading to increased side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, fatigue, and nausea. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Precon is often used during pregnancy for specific indications like threatened or recurrent miscarriage and luteal phase support, under medical supervision. Generally considered safe during lactation, but consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Progesterone is a well-established hormone, and numerous clinical trials have supported its efficacy and safety in various indications over decades.
Lab Monitoring
- Periodic liver function tests
- Coagulation status (especially with prolonged use)
- Blood pressure monitoring
Doctor Notes
- Prescribe based on clear clinical indication and patient's medical history.
- Monitor for signs of thromboembolic events, especially in patients with risk factors.
- Advise patients on potential side effects like drowsiness and counsel on administration.
- Regular follow-up is recommended, particularly for long-term therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause drowsiness or dizziness. Exercise caution while driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Avoid smoking and excessive alcohol consumption.
- Regular exercise as advised by your doctor.
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Global Brand Names
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