Adults

Dosage varies widely depending on the condition being treated and patient response, typically ranging from 5 mg to 60 mg orally per day, often initiated at higher doses and then gradually tapered. For 5mg tablets, often used for maintenance or tapering.

Elderly

Lower initial doses may be considered for elderly patients, especially those with comorbidities or at increased risk of side effects.

Renal_impairment

No specific dosage adjustment is usually required for mild to moderate renal impairment, but caution is advised in severe cases.

Onset

Onset of action typically occurs within 1-2 hours, but clinical effects may take longer to manifest.

Excretion

Excreted mainly in the urine as inactive metabolites.

Half life

Plasma half-life: 2-4 hours; Biological half-life: 18-36 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract after oral administration.

Metabolism

Primarily metabolized in the liver, mainly by CYP3A4, to inactive metabolites.

Warfarin

Altered anticoagulant effect; close monitoring of INR is required.

CYP3A4 Inhibitors/Inducers

May alter prednisolone levels (e.g., ketoconazole increases, rifampicin decreases).

Diuretics (Thiazide or Loop)

Increased risk of hypokalemia.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Increased risk of gastrointestinal bleeding and ulceration.