Medicine Information

Pregaben

Name: Pregaben
Brand: Pregaben

Capsule150 mgAnticonvulsant, Neuropathic pain agent, AnxiolyticATC: N03AX16

Generic Name

Pregabalin 150 mg capsule

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
pregaben 150 mg capsule	৳ 30.00	৳ 300.00

Description

Overview of the medicine

Pregabalin is a gamma-aminobutyric acid (GABA) analogue used to treat neuropathic pain, fibromyalgia, partial-onset seizures, and generalized anxiety disorder.

Uses & Indications

Neuropathic pain (e.g., diabetic peripheral neuropathic pain, post-herpetic neuralgia, spinal cord injury-associated neuropathic pain)

Fibromyalgia

Generalized Anxiety Disorder (GAD)

Adjunctive therapy for partial-onset seizures in adults

Dosage

Adults

Typically initiated at 75 mg twice daily or 50 mg three times daily, titrated up to 150 mg twice daily (300 mg/day) or 100 mg three times daily, depending on indication and patient response. Max 600 mg/day.

Elderly

Dose reduction often needed due to age-related decrease in renal function. Starting dose may be lower.

Renal_impairment

Dosage adjustment is required based on creatinine clearance. For CrCl 30-60 mL/min, maximum dose 300 mg/day; for CrCl 15-30 mL/min, maximum dose 150 mg/day; for CrCl <15 mL/min, maximum dose 75 mg/day.

How to Take

Pregaben capsules are for oral administration. They can be taken with or without food.

Mechanism of Action

Pregabalin binds to the alpha2-delta (α2δ) subunit of voltage-gated calcium channels in the CNS, reducing the release of several neurotransmitters, including glutamate, norepinephrine, substance P, and calcitonin gene-related peptide. This reduces neuronal excitability.

Pharmacokinetics

Onset

Pain relief within 1 week for some conditions, anxiety relief within 1 week.

Excretion

Primarily excreted unchanged in urine (approximately 98% of the dose).

Half life

Approximately 6.3 hours.

Absorption

Rapidly absorbed after oral administration, bioavailability >90%. Peak plasma concentrations achieved within 1.5 hours.

Metabolism

Negligible hepatic metabolism (less than 0.1% of the dose is metabolized).

Side Effects

Contraindications

Hypersensitivity to pregabalin or any component of the formulation.

Drug Interactions

ACE inhibitors

Co-administration may lead to an increased risk of angioedema.

Thiazolidinediones

Co-administration may result in an increased risk of weight gain and peripheral edema.

CNS depressants (opioids, benzodiazepines, ethanol)

May potentiate the effects of alcohol and other CNS depressants, leading to increased sedation and respiratory depression.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Management is supportive care, including gastric lavage if ingestion is recent. Hemodialysis may be beneficial in severe cases.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk, so caution is advised when administered to a nursing woman.

Side Effects

Contraindications

Hypersensitivity to pregabalin or any component of the formulation.

Drug Interactions

ACE inhibitors

Co-administration may lead to an increased risk of angioedema.

Thiazolidinediones

Co-administration may result in an increased risk of weight gain and peripheral edema.

CNS depressants (opioids, benzodiazepines, ethanol)

May potentiate the effects of alcohol and other CNS depressants, leading to increased sedation and respiratory depression.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules

Shelf Life

Typically 2-3 years from manufacturing date

Availability

Pharmacies

Approval Status

Approved by FDA/DGDA

Patent Status

Generic available

Clinical Trials

Pregabalin has undergone extensive clinical trials supporting its efficacy and safety for various indications, including neuropathic pain, fibromyalgia, and generalized anxiety disorder.

Lab Monitoring

No routine laboratory monitoring is generally required. Renal function should be monitored for dose adjustments in patients with impaired kidney function.

Doctor Notes

Emphasize gradual tapering upon discontinuation to minimize withdrawal symptoms.
Exercise caution when co-administering with other CNS depressants due to increased risk of sedation and respiratory depression.
Monitor patients for signs of abuse or misuse, particularly those with a history of substance abuse.
Educate patients on potential side effects like dizziness and somnolence, advising against activities requiring mental alertness initially.

Patient Guidelines

Do not stop taking Pregaben abruptly, as it may lead to withdrawal symptoms. Consult your doctor for gradual dose reduction.
This medicine may cause dizziness or somnolence. Avoid driving or operating heavy machinery until you know how it affects you.
Avoid alcohol consumption while taking Pregaben.
Report any swelling, skin reactions, or changes in mood or behavior to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Pregabalin may cause dizziness, somnolence, and blurred vision, which could impair your ability to drive or operate machinery. Patients should be advised to exercise caution.