Pregnid
Generic Name
Progesterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pregnid capsule | ৳ 3.62 | ৳ 25.33 |
Description
Overview of the medicine
Pregnid is a brand of Progesterone, a naturally occurring steroid hormone essential for the regulation of ovulation and menstruation. It is widely used to support pregnancy and treat various gynecological conditions related to progesterone deficiency.
Uses & Indications
Dosage
Adults
For luteal support: 200-400 mg daily, usually in divided doses. For threatened abortion: 200-400 mg twice daily. For other indications, dosage varies.
Elderly
No specific dosage adjustment usually needed, but caution should be exercised in elderly patients with pre-existing liver or renal impairment.
Renal_impairment
Use with caution; close monitoring of clinical response and potential adverse effects is advised as progesterone is metabolized and excreted. No specific dose adjustment guidelines are available.
How to Take
Oral capsules are typically taken with food, preferably at bedtime, to reduce drowsiness. Vaginal administration is also possible for some indications.
Mechanism of Action
Progesterone binds to progesterone receptors in target cells, particularly in the uterus, leading to changes in gene expression. It induces secretory changes in the endometrium, makes it receptive to embryo implantation, and maintains pregnancy by relaxing uterine smooth muscle and suppressing uterine contractions. It also inhibits gonadotropin secretion.
Pharmacokinetics
Onset
Effects on endometrium typically begin within hours; peak plasma concentrations reached within 1-3 hours after oral administration.
Excretion
Primarily excreted in urine (50-60%) and feces (10%) as metabolites.
Half life
Plasma half-life is approximately 5 to 20 hours, highly variable.
Absorption
Well absorbed orally but undergoes extensive first-pass metabolism in the liver, resulting in low bioavailability. Vaginal administration avoids first-pass metabolism, leading to higher systemic exposure.
Metabolism
Primarily metabolized in the liver, mainly by reduction and hydroxylation, followed by conjugation with glucuronic acid and sulfate.
Side Effects
Contraindications
- Known hypersensitivity to progesterone or any components
- Undiagnosed vaginal bleeding
- Known or suspected breast cancer or other hormone-sensitive malignancies
- Active arterial or venous thromboembolic disease
- Severe hepatic dysfunction or disease
Drug Interactions
Other hormonal preparations
Concurrent use with estrogens may modify effects of both hormones.
Cytochrome P450 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase progesterone plasma concentrations, potentially leading to increased side effects.
Cytochrome P450 inducers (e.g., Rifampicin, Phenytoin, Carbamazepine)
May decrease progesterone plasma concentrations, potentially reducing its therapeutic effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include drowsiness, dizziness, or breakthrough bleeding. Treatment is generally symptomatic and supportive, as there is no specific antidote.
Pregnancy & Lactation
Progesterone is vital for establishing and maintaining pregnancy. It is often prescribed for luteal phase support and to prevent miscarriage. It is excreted in breast milk, but generally considered compatible with breastfeeding at recommended doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical data and trials support the efficacy and safety of micronized progesterone in its approved indications, particularly for luteal phase support and recurrent miscarriage prevention.
Lab Monitoring
- Regular monitoring of liver function tests, especially in patients with pre-existing hepatic impairment.
- Periodic monitoring of lipid profile and blood glucose, particularly during long-term use.
- Monitoring for signs of thromboembolism.
Doctor Notes
- Crucial for luteal phase support in assisted reproductive technologies.
- Monitor patients for signs of thromboembolic events, especially with a history of such conditions.
- Dosage and duration of treatment must be individualized based on the patient's condition and response.
- Advise patients on the importance of adherence to the prescribed regimen.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not discontinue the medication abruptly without consulting your doctor.
- Report any unusual or severe side effects immediately.
- Be aware of potential dizziness or drowsiness, especially when driving or operating machinery.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Pregnid may cause drowsiness or dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular, moderate exercise.
- Avoid smoking and excessive alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.