Adults

Dosage varies widely depending on the condition being treated and patient response. Typically ranges from 5 mg to 60 mg daily, given as a single dose or divided doses. For Prentox 6 mg, a common starting dose might be 6-30 mg daily.

Elderly

No specific dose adjustment is usually required, but caution is advised due to increased risk of side effects. Lower effective doses should be considered.

Renal_impairment

No dosage adjustment is generally needed for renal impairment, but clinical monitoring is recommended.

Onset

Anti-inflammatory effects typically begin within 1-2 hours after oral administration.

Excretion

Mainly excreted in the urine as inactive metabolites and, to a lesser extent, as unchanged drug.

Half life

Plasma half-life is approximately 2-4 hours, but the biological half-life (duration of action) is 18-36 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations usually occur within 1-2 hours.

Metabolism

Primarily metabolized in the liver to inactive metabolites, including conjugation with sulfates and glucuronides.

Oral contraceptives

May increase prednisolone levels.

Diuretics (e.g., Furosemide)

Increased risk of hypokalemia (low potassium levels).

Warfarin and other anticoagulants

Altered anticoagulant effect; close monitoring of INR is required.

Phenytoin, Phenobarbital, Rifampicin

May decrease prednisolone levels due to increased hepatic metabolism.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Increased risk of gastrointestinal ulceration and bleeding.

Antidiabetic agents (e.g., Insulin, Metformin)

Corticosteroids can increase blood glucose levels, potentially requiring adjustment of antidiabetic medication.