Preroid
Generic Name
Prednisolone
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| preroid 5 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Preroid 5 mg Tablet contains Prednisolone, a synthetic glucocorticoid primarily used for its potent anti-inflammatory and immunosuppressive effects. It is effective in treating a wide range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition being treated and patient response. Typically, initial doses range from 5 mg to 60 mg daily, given as a single dose or in divided doses. Maintenance doses are usually lower and should be tapered gradually.
Elderly
No specific dosage adjustments are typically required for elderly patients, but they may be more susceptible to adverse effects. Start with the lowest effective dose and monitor closely.
Renal_impairment
No specific dosage adjustment is generally needed for renal impairment, as prednisolone is primarily metabolized in the liver. However, monitor for fluid and electrolyte balance.
How to Take
Take Preroid 5 mg Tablet orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break it.
Mechanism of Action
Prednisolone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus. This complex modulates gene expression, leading to the synthesis of anti-inflammatory proteins and the inhibition of pro-inflammatory mediators. It suppresses the immune system by inhibiting the function of lymphocytes and other immune cells.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within 1-2 hours, but full therapeutic effects may take longer.
Excretion
Excreted mainly in the urine as inactive metabolites and, to a lesser extent, as unchanged drug. A small amount is excreted in the feces.
Half life
Plasma elimination half-life is 2-3 hours; however, the biological half-life (duration of action) is much longer, approximately 18-36 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Prednisolone is primarily metabolized in the liver to inactive metabolites. It is also converted from prednisone (a prodrug) in the liver.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any component of the tablet
- Administration of live or live-attenuated vaccines during prednisolone therapy (especially high doses)
Drug Interactions
Antidiabetics
May increase blood glucose levels, necessitating adjustments in antidiabetic medication.
Diuretics (Thiazide and Loop)
May enhance potassium depletion, requiring potassium supplementation.
Anticoagulants (e.g., Warfarin)
Prednisolone may alter the effects of anticoagulants; dosage adjustments may be necessary.
Phenobarbital, Phenytoin, Rifampin
These drugs can increase the metabolism of prednisolone, reducing its efficacy.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with corticosteroids is generally not life-threatening. Chronic overdose can lead to signs of Cushing's syndrome (e.g., fluid retention, moon face, striae, osteoporosis). Treatment is symptomatic and supportive, including gradual reduction or withdrawal of the drug.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised when administered to a nursing mother. Monitor infants for signs of adrenal suppression.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any component of the tablet
- Administration of live or live-attenuated vaccines during prednisolone therapy (especially high doses)
Drug Interactions
Antidiabetics
May increase blood glucose levels, necessitating adjustments in antidiabetic medication.
Diuretics (Thiazide and Loop)
May enhance potassium depletion, requiring potassium supplementation.
Anticoagulants (e.g., Warfarin)
Prednisolone may alter the effects of anticoagulants; dosage adjustments may be necessary.
Phenobarbital, Phenytoin, Rifampin
These drugs can increase the metabolism of prednisolone, reducing its efficacy.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with corticosteroids is generally not life-threatening. Chronic overdose can lead to signs of Cushing's syndrome (e.g., fluid retention, moon face, striae, osteoporosis). Treatment is symptomatic and supportive, including gradual reduction or withdrawal of the drug.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised when administered to a nursing mother. Monitor infants for signs of adrenal suppression.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisolone has undergone extensive clinical trials over decades, establishing its efficacy and safety profile across various inflammatory and autoimmune conditions. Ongoing research continues to explore optimized dosing regimens and long-term effects.
Lab Monitoring
- Blood pressure monitoring
- Blood glucose monitoring (especially in diabetics)
- Electrolyte levels (potassium, sodium)
- Bone mineral density (for long-term therapy)
- Growth monitoring in children
- Ophthalmic exams (for long-term therapy)
Doctor Notes
- Emphasize gradual tapering of dose to prevent adrenal insufficiency.
- Educate patients on potential long-term side effects and the importance of regular monitoring.
- Consider calcium and vitamin D supplementation for patients on long-term therapy to mitigate osteoporosis risk.
- Monitor blood glucose levels, blood pressure, and signs of infection diligently.
Patient Guidelines
- Do not stop taking Preroid suddenly without consulting your doctor, as this can lead to serious withdrawal symptoms.
- Always take this medicine with food or milk to reduce stomach irritation.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any signs of infection (fever, sore throat) to your doctor immediately, as corticosteroids can mask symptoms of infection.
- Avoid close contact with people who have chickenpox or measles if you have not had these diseases or been vaccinated.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Preroid 5 mg Tablet may cause dizziness, visual disturbances, or mood changes in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health, especially with long-term use.
- Engage in regular, moderate exercise (as advised by your doctor) to help maintain muscle strength and bone density.
- Avoid excessive alcohol consumption and smoking, as these can exacerbate some side effects.
- Limit salt intake to reduce fluid retention.
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