Pretin
Generic Name
Prednisolone 10 mg tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pretin 10 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Pretin 10 mg Tablet contains Prednisolone, a corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, including allergies, asthma, arthritis, and skin disorders. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Initial dosage varies widely based on condition, typically 5-60 mg/day orally in single or divided doses. Tapering is often necessary for long-term use.
Elderly
Lower doses may be required, and patients should be monitored for adverse effects. Consider age-related decrease in renal/hepatic function and comorbidities.
Renal_impairment
No specific dose adjustment typically required, but monitor for fluid retention and electrolyte imbalance.
How to Take
Administer orally, preferably with food or milk to minimize gastric irritation. Take exactly as prescribed by your doctor. Do not stop abruptly.
Mechanism of Action
Prednisolone, a synthetic glucocorticoid, exerts its action by binding to specific intracellular glucocorticoid receptors. This complex then translocates to the nucleus, modifying gene expression, leading to the synthesis of anti-inflammatory proteins (e.g., lipocortin) and inhibition of pro-inflammatory mediators (e.g., cytokines, chemokines, prostaglandins, leukotrienes). It also suppresses immune response by affecting lymphocyte function and migration.
Pharmacokinetics
Onset
Anti-inflammatory effects typically within 1-2 hours, peak effect around 1-2 days for chronic conditions.
Excretion
Mainly excreted in urine as inactive metabolites and some unchanged drug.
Half life
Biological half-life 18-36 hours; plasma half-life 2-4 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver to inactive metabolites. Also undergoes enterohepatic recirculation.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Warfarin
Altered anticoagulant effect; monitor INR.
NSAIDs (e.g., Ibuprofen)
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
Phenytoin, Phenobarbital, Rifampicin
May decrease corticosteroid effects by inducing hepatic metabolism.
Antidiabetics (e.g., Insulin, Metformin)
May increase blood glucose levels, requiring dose adjustment of antidiabetics.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and usually does not lead to life-threatening situations. Chronic overdose can lead to severe side effects such as Cushingoid features, hypertension, and diabetes. Treatment is symptomatic and supportive. Gradually taper the dose.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Prednisolone is excreted in breast milk and may cause adverse effects in infants. Consult your doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Warfarin
Altered anticoagulant effect; monitor INR.
NSAIDs (e.g., Ibuprofen)
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
Phenytoin, Phenobarbital, Rifampicin
May decrease corticosteroid effects by inducing hepatic metabolism.
Antidiabetics (e.g., Insulin, Metformin)
May increase blood glucose levels, requiring dose adjustment of antidiabetics.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and usually does not lead to life-threatening situations. Chronic overdose can lead to severe side effects such as Cushingoid features, hypertension, and diabetes. Treatment is symptomatic and supportive. Gradually taper the dose.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Prednisolone is excreted in breast milk and may cause adverse effects in infants. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date.
Availability
Available in pharmacies, hospitals, and medical stores nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory and autoimmune conditions since its introduction. Ongoing research explores its role in new therapeutic areas and optimal dosing strategies.
Lab Monitoring
- Blood glucose levels
- Electrolytes (especially potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Ophthalmological exams (for long-term use)
Doctor Notes
- Emphasize slow tapering to prevent adrenal crisis.
- Monitor blood pressure, blood glucose, and electrolytes regularly, especially in long-term therapy.
- Consider calcium and vitamin D supplementation for patients on chronic therapy to mitigate osteoporosis risk.
- Advise patients on infection prevention strategies.
Patient Guidelines
- Take with food to reduce stomach upset.
- Do not stop taking this medication abruptly; follow your doctor's instructions for tapering the dose.
- Report any unusual weight gain, swelling, or changes in mood.
- Avoid contact with people who have infections, especially chickenpox or measles, while on this medication.
- Carry a steroid warning card, especially if on long-term therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose. If on a tapering schedule, consult your doctor.
Driving Precautions
This medication may cause dizziness or blurred vision in some individuals. If you experience these effects, avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Limit sodium intake to reduce fluid retention.
- Engage in regular, moderate exercise, if medically appropriate, to maintain muscle strength and bone density.
- Avoid excessive alcohol consumption.
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