Previp
Generic Name
Losartan Potassium
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| previp 50 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Previp 50 mg Tablet is used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes. It works by relaxing blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
Initial dose: 50 mg once daily. May be increased to 100 mg once daily if needed. For patients with possible intravascular volume depletion, a lower initial dose of 25 mg once daily is recommended.
Elderly
No initial dosage adjustment is typically needed, but consider starting with 25 mg for very frail or volume-depleted patients.
Renal_impairment
No initial dosage adjustment is necessary for mild to moderate renal impairment. For severe renal impairment or dialysis, a lower starting dose (e.g., 25 mg) may be considered.
How to Take
Previp 50 mg Tablet should be taken orally with or without food, usually once daily. It is important to take it at about the same time each day.
Mechanism of Action
Losartan is an angiotensin II receptor blocker (ARB). It selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues (e.g., vascular smooth muscle, adrenal gland). This blockade prevents the vasoconstricting and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect begins within 6 hours, full effect within 3-6 weeks.
Excretion
Approximately 35% excreted in urine and 60% in feces, mainly as unchanged drug and its active metabolite.
Half life
Losartan: 2 hours; active metabolite (E-3174): 6-9 hours.
Absorption
Well absorbed after oral administration, with an oral bioavailability of about 33%. Peak plasma concentrations are reached in about 1 hour for Losartan and 3-4 hours for its active metabolite.
Metabolism
Undergoes extensive first-pass metabolism by CYP2C9 and CYP3A4 to an active carboxylic acid metabolite (E-3174), which is more potent than Losartan.
Side Effects
Contraindications
- Hypersensitivity to Losartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with Aliskiren in patients with diabetes or renal impairment (GFR <60 ml/min/1.73m²)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported. Monitor lithium levels carefully.
Diuretics (e.g., Furosemide)
May enhance the hypotensive effect, especially at initiation. Monitor blood pressure closely.
Other antihypertensive agents
Additive hypotensive effects may occur.
NSAIDs (e.g., Ibuprofen, Naproxen)
May attenuate the antihypertensive effect and increase the risk of renal function deterioration, especially in elderly, volume-depleted, or renally impaired patients.
Potassium-sparing diuretics (e.g., Spironolactone) or Potassium supplements
May increase serum potassium levels, leading to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to include hypotension (low blood pressure) and tachycardia. Bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Administer activated charcoal to reduce absorption. Monitor vital signs and fluid/electrolyte balance.
Pregnancy & Lactation
Pregnancy: Contraindicated during the second and third trimesters due to fetal toxicity. Discontinue Previp immediately if pregnancy is detected. Lactation: Not recommended. It is unknown if Losartan is excreted in human milk. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Losartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with Aliskiren in patients with diabetes or renal impairment (GFR <60 ml/min/1.73m²)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported. Monitor lithium levels carefully.
Diuretics (e.g., Furosemide)
May enhance the hypotensive effect, especially at initiation. Monitor blood pressure closely.
Other antihypertensive agents
Additive hypotensive effects may occur.
NSAIDs (e.g., Ibuprofen, Naproxen)
May attenuate the antihypertensive effect and increase the risk of renal function deterioration, especially in elderly, volume-depleted, or renally impaired patients.
Potassium-sparing diuretics (e.g., Spironolactone) or Potassium supplements
May increase serum potassium levels, leading to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to include hypotension (low blood pressure) and tachycardia. Bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Administer activated charcoal to reduce absorption. Monitor vital signs and fluid/electrolyte balance.
Pregnancy & Lactation
Pregnancy: Contraindicated during the second and third trimesters due to fetal toxicity. Discontinue Previp immediately if pregnancy is detected. Lactation: Not recommended. It is unknown if Losartan is excreted in human milk. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Patent expired, generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., LIFE study, RENAAL study) have demonstrated the efficacy of Losartan in reducing cardiovascular morbidity and mortality, and in preventing renal disease progression in diabetic nephropathy.
Lab Monitoring
- Blood pressure
- Serum potassium levels (especially in patients with renal impairment or those taking potassium-sparing diuretics)
- Renal function (BUN, creatinine, GFR)
- Liver function tests (periodically)
Doctor Notes
- Emphasize the importance of consistent daily dosing.
- Advise caution in patients with hepatic impairment due to increased plasma concentrations of Losartan.
- Monitor electrolytes, particularly potassium, and renal function regularly.
Patient Guidelines
- Take Previp exactly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor, even if you feel well.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs, supplements, and herbal products.
- Avoid potassium supplements or salt substitutes containing potassium without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Previp may cause dizziness or lightheadedness, especially when starting treatment or increasing the dose. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Limit alcohol intake.
- Quit smoking.
- Monitor your blood pressure regularly at home if advised.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.