Prindol
Generic Name
Indomethacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prindol 3 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and joint stiffness caused by arthritis, bursitis, and tendinitis. It is also used to treat gout attacks and certain types of headaches.
Uses & Indications
Dosage
Adults
Typically 25 mg to 50 mg, 2-3 times daily, not exceeding 200 mg/day.
Elderly
Lower doses may be required due to increased sensitivity and risk of adverse effects.
Renal_impairment
Adjust dosage based on creatinine clearance; use with caution.
How to Take
Take orally with food, milk, or antacids to minimize gastrointestinal upset. Swallow capsules whole.
Mechanism of Action
Indomethacin works by inhibiting the production of certain natural substances in your body that cause inflammation. It blocks the cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins, leading to reduced pain, swelling, and fever.
Pharmacokinetics
Onset
Within 30 minutes for pain relief, 1-2 hours for anti-inflammatory.
Excretion
Mainly via urine (60%) and feces (33%).
Half life
4.5 to 6 hours.
Absorption
Rapidly and almost completely absorbed from the GI tract.
Metabolism
Primarily in the liver by O-demethylation and N-deacylation.
Side Effects
Contraindications
- Hypersensitivity to indomethacin or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium plasma levels and toxicity.
Warfarin
Increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
ACE inhibitors
Reduced antihypertensive effect.
Storage
Store below 30°C, in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, severe headache, dizziness, disorientation, and drowsiness. Management includes symptomatic and supportive care, gastric emptying (e.g., induced emesis or gastric lavage) and administration of activated charcoal.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution during early pregnancy only if clearly needed. Indomethacin is excreted in breast milk; therefore, use is not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to indomethacin or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium plasma levels and toxicity.
Warfarin
Increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
ACE inhibitors
Reduced antihypertensive effect.
Storage
Store below 30°C, in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, severe headache, dizziness, disorientation, and drowsiness. Management includes symptomatic and supportive care, gastric emptying (e.g., induced emesis or gastric lavage) and administration of activated charcoal.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution during early pregnancy only if clearly needed. Indomethacin is excreted in breast milk; therefore, use is not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
DGDA Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have been conducted since its approval in 1965, establishing its efficacy and safety for the treatment of various inflammatory and painful conditions. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Caution in elderly patients and those with cardiovascular or renal risk factors.
- Always inquire about history of NSAID sensitivity.
Patient Guidelines
- Take with food to reduce stomach upset.
- Do not lie down for at least 10 minutes after taking.
- Report any signs of stomach bleeding (black stools, vomiting blood) immediately.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Indomethacin may cause dizziness, drowsiness, or blurred vision. If you experience these effects, avoid driving or operating machinery.
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