Priovit
Generic Name
Pyridoxine Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| priovit 6 mg tablet | ৳ 2.50 | N/A |
Description
Overview of the medicine
Priovit 6 mg Tablet contains Pyridoxine (Vitamin B6), a water-soluble vitamin essential for various metabolic processes in the body, including amino acid metabolism, neurotransmitter synthesis, and red blood cell formation. It helps maintain nerve, skin, and red blood cell health.
Uses & Indications
Dosage
Adults
For vitamin B6 deficiency: 2.5-10 mg daily for 3 weeks, then 2-5 mg daily as a maintenance dose. For drug-induced deficiency: 10-50 mg daily. For nausea of pregnancy: Typically 10-25 mg, 3-4 times daily (often combined).
Elderly
No specific dose adjustment is generally required, follow adult dosage.
Renal_impairment
No specific dose adjustment is generally required, use with caution in severe impairment.
How to Take
Take orally with or without food, as directed by a healthcare professional. Swallow the tablet whole with water.
Mechanism of Action
Pyridoxine is converted to its active form, pyridoxal-5-phosphate (PLP), which acts as a coenzyme in numerous metabolic reactions, primarily involved in amino acid, carbohydrate, and lipid metabolism. It plays a crucial role in neurotransmitter synthesis (e.g., serotonin, dopamine), hemoglobin formation, and immune function.
Pharmacokinetics
Onset
Therapeutic effects are generally observed within days to weeks depending on the deficiency severity.
Excretion
Excreted primarily in the urine as inactive metabolites.
Half life
Approximately 15-20 days (for PLP, the active form) though some sources cite 2-3 hours for unconverted pyridoxine.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the jejunum. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver to pyridoxal-5-phosphate (PLP), the active coenzyme, and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to pyridoxine or any component of the formulation.
Drug Interactions
Levodopa
Pyridoxine can decrease the effectiveness of levodopa (used for Parkinson's disease) by increasing its peripheral metabolism. This interaction is usually significant with higher doses of B6 and can be overcome if levodopa is given with carbidopa.
Isoniazid, Penicillamine, Hydralazine, Cycloserine, Oral Contraceptives
These drugs can increase pyridoxine requirements or interfere with its metabolism, leading to deficiency. Pyridoxine supplementation may be necessary.
Storage
Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
At typical doses, pyridoxine is safe. However, chronic intake of very high doses (e.g., >200 mg/day for prolonged periods) can lead to sensory neuropathy (nerve damage) characterized by numbness and tingling, muscle weakness, and impaired coordination. Management involves discontinuing the supplement.
Pregnancy & Lactation
Pyridoxine is considered safe and often recommended during pregnancy, especially for managing nausea and vomiting. It is also safe during lactation, as it is naturally present in breast milk and supplementation does not typically pose a risk to the infant.
Side Effects
Contraindications
- Hypersensitivity to pyridoxine or any component of the formulation.
Drug Interactions
Levodopa
Pyridoxine can decrease the effectiveness of levodopa (used for Parkinson's disease) by increasing its peripheral metabolism. This interaction is usually significant with higher doses of B6 and can be overcome if levodopa is given with carbidopa.
Isoniazid, Penicillamine, Hydralazine, Cycloserine, Oral Contraceptives
These drugs can increase pyridoxine requirements or interfere with its metabolism, leading to deficiency. Pyridoxine supplementation may be necessary.
Storage
Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
At typical doses, pyridoxine is safe. However, chronic intake of very high doses (e.g., >200 mg/day for prolonged periods) can lead to sensory neuropathy (nerve damage) characterized by numbness and tingling, muscle weakness, and impaired coordination. Management involves discontinuing the supplement.
Pregnancy & Lactation
Pyridoxine is considered safe and often recommended during pregnancy, especially for managing nausea and vomiting. It is also safe during lactation, as it is naturally present in breast milk and supplementation does not typically pose a risk to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Drugstores
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical use has established Pyridoxine's efficacy and safety for B6 deficiency. Specific trials for 6 mg are rare, as it's a well-known essential vitamin.
Lab Monitoring
- No routine lab monitoring is required for pyridoxine supplementation at 6 mg.
Doctor Notes
- Pyridoxine 6 mg is primarily for daily supplementation or mild deficiency.
- For severe deficiency or specific conditions (e.g., drug-induced neuropathy), higher doses may be required under medical supervision.
- Advise patients on dietary sources of Vitamin B6.
Patient Guidelines
- Take as directed, do not exceed recommended dose.
- Inform your doctor about all medications and supplements you are taking.
- Seek medical advice if you experience unusual symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Priovit 6 mg Tablet is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in essential vitamins and minerals.
- Avoid excessive alcohol consumption as it can interfere with vitamin absorption.
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