Pro-Medrol
Generic Name
pro-medrol-1-gm-injection
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pro medrol 1 gm injection | ৳ 1,000.00 | N/A |
Description
Overview of the medicine
Pro-Medrol 1 gm Injection contains Methylprednisolone, a synthetic glucocorticoid. It is used for its potent anti-inflammatory and immunosuppressive effects in various conditions.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the disease being treated and patient response. Typically ranges from 125 mg to 1 gm or more daily, administered IV or IM, usually over short courses or tapered. Consult specific guidelines for severe conditions.
Elderly
Similar to adult dosage, but caution should be exercised due to increased risk of side effects (e.g., osteoporosis, fluid retention).
Renal_impairment
Generally no dosage adjustment is required for renal impairment, but careful monitoring is advised.
How to Take
Pro-Medrol 1 gm Injection should be administered by a healthcare professional via intravenous (IV) or intramuscular (IM) route. For IV administration, it can be given as a slow bolus or infused over a prescribed period.
Mechanism of Action
Methylprednisolone acts by binding to glucocorticoid receptors, modifying gene expression to inhibit the synthesis of inflammatory mediators and suppress immune responses.
Pharmacokinetics
Onset
Within minutes to hours for IV administration, longer for IM.
Excretion
Excreted mainly via urine as inactive metabolites.
Half life
Plasma half-life is approximately 2.5-3.5 hours, but biological half-life is 18-36 hours.
Absorption
Rapidly absorbed after intravenous (IV) or intramuscular (IM) administration.
Metabolism
Primarily metabolized in the liver by cytochrome P450 (CYP3A4) enzymes.
Side Effects
Contraindications
- •Systemic fungal infections
- •Known hypersensitivity to methylprednisolone or any component of the formulation
- •Live or live-attenuated vaccines when on immunosuppressive doses
Drug Interactions
Warfarin
May alter anticoagulant effects; require close monitoring of INR.
Oral Contraceptives
May increase corticosteroid effects.
Diuretics (Thiazide or Loop)
May enhance potassium depletion; monitor potassium levels.
Phenytoin, Barbiturates, Rifampicin
May decrease corticosteroid effects by inducing hepatic metabolism.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding.
Storage
Store intact vials at controlled room temperature (20-25°C), protected from light. After reconstitution, stability varies; use immediately or as directed by manufacturer.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hypertension, hyperglycemia, and electrolyte imbalance. Management is primarily symptomatic and supportive; specific antidote is not available. Chronic overdose may lead to Cushingoid features.
Pregnancy & Lactation
Methylprednisolone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, but varies by manufacturer and specific product. Refer to the product packaging for exact expiry date.
Availability
Hospitals, retail pharmacies
Approval Status
Generally approved by major regulatory bodies (e.g., FDA, EMA, DGDA) as Methylprednisolone.
Patent Status
Patent expired, generics available.
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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