Probal-DX
Generic Name
Calcium Carbonate + Cholecalciferol (Vitamin D3)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| probal dx 600 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Probal-DX 600 mg Tablet is a combination of Calcium Carbonate and Vitamin D3 (Cholecalciferol) used to prevent and treat calcium and vitamin D deficiencies, primarily for maintaining bone health and preventing osteoporosis.
Uses & Indications
Dosage
Adults
1 to 2 tablets daily, or as directed by a physician.
Elderly
Same as adult dosage, but caution should be exercised in patients with renal impairment.
Renal_impairment
Use with caution; dose adjustment may be necessary based on calcium and phosphate levels. Avoid in severe renal impairment.
How to Take
Oral administration. Can be taken with or without food, but taking with meals may improve absorption and reduce gastric upset.
Mechanism of Action
Calcium Carbonate provides elemental calcium, an essential mineral for bone formation and maintenance, nerve transmission, muscle contraction, and many other bodily functions. Vitamin D3 (Cholecalciferol) enhances the absorption of calcium from the gastrointestinal tract and regulates calcium and phosphate homeostasis.
Pharmacokinetics
Onset
Effects on bone density are gradual, over weeks to months.
Excretion
Calcium is excreted mainly via feces, with some renal excretion. Vitamin D metabolites are primarily excreted in the bile and feces.
Half life
Calcium's half-life varies. Cholecalciferol has a half-life of about 15-20 days.
Absorption
Calcium carbonate is absorbed primarily in the small intestine, requiring gastric acid for dissolution. Cholecalciferol is readily absorbed from the small intestine, especially in the presence of bile salts.
Metabolism
Calcium is not metabolized. Cholecalciferol is hydroxylated in the liver to 25-hydroxyvitamin D3 and then in the kidneys to the active form, 1,25-dihydroxyvitamin D3.
Side Effects
Contraindications
- Hypercalcemia (high blood calcium levels)
- Hypercalciuria (high urine calcium levels)
- Severe renal impairment
- Known hypersensitivity to calcium carbonate, cholecalciferol, or any components of the formulation
Drug Interactions
Levothyroxine
Calcium can impair absorption; administer at least 4 hours apart.
Bisphosphonates
Calcium can reduce their absorption; administer at least 30 minutes apart.
Cardiac glycosides
Increased risk of arrhythmias.
Thiazide diuretics
May increase the risk of hypercalcemia.
Tetracyclines & Quinolones
Calcium can decrease their absorption; administer at least 2 hours before or 4-6 hours after.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, polyuria, polydipsia, muscle weakness, kidney stones). Treatment involves discontinuing the product, hydration, and medical management of hypercalcemia.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation for adequate calcium and vitamin D intake, but should be used under medical supervision. Category C for Cholecalciferol (in high doses), Category B for Calcium Carbonate.
Side Effects
Contraindications
- Hypercalcemia (high blood calcium levels)
- Hypercalciuria (high urine calcium levels)
- Severe renal impairment
- Known hypersensitivity to calcium carbonate, cholecalciferol, or any components of the formulation
Drug Interactions
Levothyroxine
Calcium can impair absorption; administer at least 4 hours apart.
Bisphosphonates
Calcium can reduce their absorption; administer at least 30 minutes apart.
Cardiac glycosides
Increased risk of arrhythmias.
Thiazide diuretics
May increase the risk of hypercalcemia.
Tetracyclines & Quinolones
Calcium can decrease their absorption; administer at least 2 hours before or 4-6 hours after.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, polyuria, polydipsia, muscle weakness, kidney stones). Treatment involves discontinuing the product, hydration, and medical management of hypercalcemia.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation for adequate calcium and vitamin D intake, but should be used under medical supervision. Category C for Cholecalciferol (in high doses), Category B for Calcium Carbonate.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies and drugstores
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of calcium and vitamin D supplementation for bone health and deficiency management.
Lab Monitoring
- Serum calcium levels
- Serum 25(OH)D levels (Vitamin D)
- Renal function (creatinine, eGFR)
Doctor Notes
- Advise patients on proper administration and potential drug-food interactions.
- Monitor serum calcium and vitamin D levels periodically, especially in patients with pre-existing conditions or on long-term therapy.
- Educate patients on symptoms of hypercalcemia and the importance of adequate hydration.
Patient Guidelines
- Take exactly as prescribed or directed on the label.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
- Report any unusual side effects to your doctor.
- Maintain adequate fluid intake.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Probal-DX is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and Vitamin D.
- Engage in regular weight-bearing exercise for bone health.
- Get adequate, safe sun exposure for natural Vitamin D synthesis.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.