Profenid
Generic Name
Ketoprofen
Manufacturer
Sanofi
Country
France (originator)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| profenid 100 mg injection | ৳ 50.15 | N/A |
Description
Overview of the medicine
Profenid 100 mg injection contains Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
The usual recommended dose is 100 mg (one ampoule) once or twice daily by intramuscular injection. Maximum daily dose should not exceed 200 mg.
Elderly
Lower doses should be considered, and patients should be carefully monitored due to increased risk of adverse effects.
Renal_impairment
Dosage reduction is necessary in patients with moderate to severe renal impairment. Avoid in severe renal failure.
How to Take
Profenid 100 mg injection is administered by deep intramuscular injection. It should not be given intravenously.
Mechanism of Action
Ketoprofen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate pain, inflammation, and fever, so by inhibiting their synthesis, Ketoprofen reduces these symptoms.
Pharmacokinetics
Onset
Analgesic effect usually starts within 30 minutes.
Excretion
Mainly excreted in urine (about 50-90% as metabolites) within 24 hours; a small amount is excreted in feces.
Half life
Approximately 1.5 to 3 hours.
Absorption
Rapid and complete absorption after intramuscular (IM) injection, reaching peak plasma concentrations within 15-30 minutes.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to ketoprofen or any other NSAID
- Active gastrointestinal bleeding, ulceration, or perforation
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
May reduce their antihypertensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, headache, and dizziness. Severe overdose can lead to renal failure, liver damage, convulsions, and respiratory depression. Management is supportive and symptomatic, with no specific antidote. Gastric lavage and activated charcoal may be considered if ingestion was recent, though less relevant for injection overdose.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to potential risk of premature closure of the fetal ductus arteriosus and renal dysfunction. Use with caution in the first and second trimesters only if clearly needed. Not recommended during breastfeeding as ketoprofen may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to ketoprofen or any other NSAID
- Active gastrointestinal bleeding, ulceration, or perforation
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
May reduce their antihypertensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, headache, and dizziness. Severe overdose can lead to renal failure, liver damage, convulsions, and respiratory depression. Management is supportive and symptomatic, with no specific antidote. Gastric lavage and activated charcoal may be considered if ingestion was recent, though less relevant for injection overdose.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to potential risk of premature closure of the fetal ductus arteriosus and renal dysfunction. Use with caution in the first and second trimesters only if clearly needed. Not recommended during breastfeeding as ketoprofen may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, depending on the manufacturer and specific formulation. Check the expiry date on the packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ketoprofen has undergone extensive clinical trials demonstrating its efficacy and safety in various pain and inflammatory conditions. Detailed trial data can be found in regulatory submissions and published medical literature.
Lab Monitoring
- Regular monitoring of renal function (serum creatinine, BUN) is recommended, especially in elderly patients or those with pre-existing renal impairment.
- Liver function tests (ALT, AST) should be monitored periodically.
- Complete blood count (CBC) and coagulation studies (e.g., INR) are advisable during long-term therapy or in patients on anticoagulants.
Doctor Notes
- Assess cardiovascular and gastrointestinal risk factors before initiating therapy, especially in elderly patients.
- Monitor renal and hepatic function regularly during prolonged treatment.
- Educate patients on symptoms of GI bleeding and cardiovascular events, and instruct them to seek immediate medical attention if these occur.
Patient Guidelines
- Do not exceed the prescribed dose or duration of treatment.
- Report any signs of gastrointestinal bleeding (black, tarry stools; severe abdominal pain; vomiting blood) immediately.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Avoid alcohol while using this medicine.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Profenid may cause dizziness, drowsiness, or visual disturbances. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hydration, especially if you have risk factors for kidney impairment. Avoid activities that may aggravate pain or inflammation.
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