Proflam-SR
Generic Name
Diclofenac Sodium (Sustained Release)
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| proflam sr 100 mg tablet | ৳ 3.01 | ৳ 30.15 |
Description
Overview of the medicine
Proflam-SR 100 mg Tablet is a sustained-release non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and inflammation associated with various conditions such as arthritis, musculoskeletal disorders, and acute pain.
Uses & Indications
Dosage
Adults
100 mg once daily, preferably with food.
Elderly
Elderly patients should be started on the lowest effective dose due to increased risk of side effects.
Renal_impairment
Use with caution; dosage adjustment may be necessary in patients with severe renal impairment. Avoid in severe renal disease.
How to Take
Take orally, preferably with or after food to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
Mechanism of Action
Diclofenac works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are chemical messengers that contribute to pain, inflammation, and fever. By reducing prostaglandin production, Diclofenac helps to reduce these symptoms.
Pharmacokinetics
Onset
Pain relief usually starts within 30-60 minutes; full effect for chronic conditions may take longer.
Excretion
Excreted predominantly in the urine (approx. 60%) and bile (approx. 35%).
Half life
Plasma half-life of parent compound is approximately 1-2 hours, but terminal elimination half-life is longer (around 8 hours for SR forms), allowing for once-daily dosing.
Absorption
Well absorbed orally; peak plasma concentrations achieved in 2-4 hours for conventional tablets, prolonged for SR forms.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and subsequent glucuronidation, mainly by CYP2C9.
Side Effects
Contraindications
- •Active peptic ulcer or gastrointestinal bleeding
- •History of hypersensitivity to diclofenac, aspirin, or other NSAIDs
- •Severe heart failure
- •Severe renal or hepatic impairment
- •Third trimester of pregnancy
- •Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Lithium/Digoxin
Increased plasma levels of these drugs.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential fetal harm. Use with caution during the first and second trimesters only if the potential benefit outweighs the risk. Diclofenac is excreted in breast milk; therefore, use is generally not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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