Profloxin
Generic Name
Ciprofloxacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| profloxin 500 mg tablet | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Profloxin is a brand of Ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Typically 250-750 mg orally twice daily, depending on the infection.
Elderly
Dosage adjustment may be necessary based on renal function.
Renal_impairment
Dose reduction required for patients with severe renal impairment (CrCl < 30 mL/min).
How to Take
Can be taken with or without food, but preferably two hours after a meal to avoid potential stomach upset. Do not take with dairy products or calcium-fortified juices alone.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Approximately 30-60 minutes.
Excretion
Primarily excreted renally (50-70% unchanged in urine) and to a lesser extent via feces.
Half life
About 3-5 hours.
Absorption
Rapidly and well absorbed after oral administration, bioavailability is about 70-80%.
Metabolism
Partially metabolized in the liver to four active metabolites; however, most is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other quinolones
- Concomitant administration with tizanidine
Drug Interactions
Caffeine
Reduced caffeine clearance
Warfarin
Enhanced anticoagulant effects
Theophylline
Increased theophylline levels and toxicity
Antacids, iron, zinc supplements
Reduce ciprofloxacin absorption
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Gastric lavage may be considered. Support and symptomatic treatment should be provided. Adequate hydration should be maintained.
Pregnancy & Lactation
Generally not recommended during pregnancy and lactation due to potential risks to the fetus/infant. Use only if potential benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of ciprofloxacin for various bacterial infections.
Lab Monitoring
- Regular monitoring of renal and hepatic function, especially during prolonged therapy.
Doctor Notes
- Consider culture and susceptibility testing before initiating treatment.
- Monitor patients for signs of tendinitis or neuropathy.
- Adjust dose for renal impairment.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Drink plenty of fluids while on this medication.
- Avoid excessive exposure to sunlight or artificial UV light.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness; caution advised when driving or operating machinery.
Lifestyle Advice
- Avoid consuming alcohol if it causes stomach upset. Maintain a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.