Progency
Generic Name
Progenamide Hydrochloride
Manufacturer
MediLife Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| progency 10 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Progency-10 mg Tablet contains Progenamide Hydrochloride, a novel antihypertensive agent primarily used to manage essential hypertension. It acts by selectively dilating peripheral blood vessels, thereby reducing blood pressure.
Uses & Indications
Dosage
Adults
Initially 10 mg once daily, adjusted based on response up to 20 mg daily.
Elderly
Start with 5 mg once daily, titrate carefully based on individual response and tolerability.
Renal_impairment
No dose adjustment needed for mild to moderate impairment. Use with caution in severe impairment; monitor blood pressure closely.
How to Take
Take orally, preferably at the same time each day, with or without food. Swallow the tablet whole with a glass of water; do not crush or chew.
Mechanism of Action
Progenamide Hydrochloride is a selective peripheral vasodilator that directly relaxes vascular smooth muscle, leading to vasodilation and a reduction in total peripheral resistance. This action helps to lower systemic blood pressure.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Primarily excreted via urine (60% as metabolites, 20% unchanged drug); remainder in feces.
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, bioavailability approximately 80%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver via CYP3A4 pathway to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Progenamide Hydrochloride or any component of the formulation
- Severe symptomatic hypotension
- Cardiogenic shock
- Severe aortic stenosis
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Progenamide Hydrochloride.
Diuretics
Concomitant use may potentiate hypotensive effects, requiring dose adjustment of either drug.
Beta-blockers
Additive hypotensive effects possible; monitor blood pressure closely.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, dizziness, profound weakness, and reflex tachycardia. Treatment is supportive and symptomatic. Gastric lavage and activated charcoal may be considered if ingestion is recent. Intravenous fluids and vasopressors may be administered to manage hypotension.
Pregnancy & Lactation
Not recommended during pregnancy unless essential, due to potential fetal risks. Progenamide Hydrochloride may be excreted in breast milk; use with caution in lactating mothers and only after consulting a doctor.
Side Effects
Contraindications
- Hypersensitivity to Progenamide Hydrochloride or any component of the formulation
- Severe symptomatic hypotension
- Cardiogenic shock
- Severe aortic stenosis
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Progenamide Hydrochloride.
Diuretics
Concomitant use may potentiate hypotensive effects, requiring dose adjustment of either drug.
Beta-blockers
Additive hypotensive effects possible; monitor blood pressure closely.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, dizziness, profound weakness, and reflex tachycardia. Treatment is supportive and symptomatic. Gastric lavage and activated charcoal may be considered if ingestion is recent. Intravenous fluids and vasopressors may be administered to manage hypotension.
Pregnancy & Lactation
Not recommended during pregnancy unless essential, due to potential fetal risks. Progenamide Hydrochloride may be excreted in breast milk; use with caution in lactating mothers and only after consulting a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Hypothetical)
Patent Status
Patented (Hypothetical)
Clinical Trials
Phase III clinical trials demonstrated significant and sustained reduction in systolic and diastolic blood pressure compared to placebo, with a favorable tolerability profile. Long-term safety and efficacy studies are ongoing as part of post-marketing surveillance.
Lab Monitoring
- Regular blood pressure monitoring
- Renal function tests (Creatinine, BUN, GFR)
- Liver function tests (ALT, AST) periodically
- Electrolyte levels (Potassium, Sodium)
Doctor Notes
- Monitor patients for signs of hypotension, especially at initiation of therapy or dose escalation.
- Advise patients on the importance of adherence to medication and lifestyle modifications for optimal blood pressure control.
- Not recommended for first-line treatment in severe heart failure due to potential for fluid retention.
- Consider dosage adjustments in patients with significant hepatic impairment.
Patient Guidelines
- Take Progency-10 mg Tablet exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly, even if your blood pressure appears normal, without consulting your doctor.
- Report any new or worsening side effects, especially swelling, dizziness, or severe headache, to your healthcare provider.
- Avoid driving or operating heavy machinery until you know how this medication affects you, as it may cause dizziness.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's close to the next scheduled dose (e.g., within 6 hours), skip the missed dose and resume your regular schedule. Do not double dose to make up for a missed one.
Driving Precautions
Progency-10 mg Tablet may cause dizziness, lightheadedness, or fatigue, especially when starting treatment or increasing the dose. Patients should exercise caution when driving or operating machinery until they are aware of how the medicine affects their ability to perform such tasks safely.
Lifestyle Advice
- Maintain a low-sodium, balanced diet.
- Engage in regular, moderate physical activity as advised by your doctor.
- Avoid smoking and excessive alcohol consumption, as these can negatively impact blood pressure.
- Manage stress through relaxation techniques.
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Global Brand Names
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