Prolert
Generic Name
Esomeprazole
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prolert 20 mg capsule | ৳ 3.01 | ৳ 30.10 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is used to treat acid-related conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily for 7-14 days (with antibiotics). Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
No specific dose adjustment is required for elderly patients.
Renal_impairment
No dose adjustment is required for patients with renal impairment.
How to Take
Take orally, generally 30-60 minutes before a meal. Swallow the capsule whole with water; do not chew or crush it. For patients who have difficulty swallowing, the capsule can be opened and the pellets mixed with water or a semi-solid food.
Mechanism of Action
Esomeprazole works by irreversibly blocking the H+/K+-ATPase enzyme (the proton pump) in the gastric parietal cells, thereby inhibiting the final step in acid production.
Pharmacokinetics
Onset
Onset of acid suppression typically occurs within 1 hour.
Excretion
Approximately 80% of metabolites are excreted in the urine and 20% in the feces.
Half life
Plasma elimination half-life is approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations typically within 1-2 hours. Bioavailability is approximately 64% after a single 40 mg dose and increases to 89% after repeated once-daily administration.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased absorption and plasma levels of digoxin.
Warfarin
Increased INR and prothrombin time; monitor closely.
Nelfinavir
Significant decrease in nelfinavir plasma levels; concomitant use is contraindicated.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Increased plasma levels of methotrexate, particularly with high doses.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and transient, including drowsiness, confusion, blurred vision, tachycardia, nausea, vomiting, and diarrhea. Treatment is symptomatic and supportive, as there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B (older classification). Use with caution during pregnancy if clearly needed, after consulting a doctor. Esomeprazole is excreted in human breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies like FDA, DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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