Prolok
Generic Name
Pantoprazole Sodium
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prolok 40 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Prolok 40 mg Injection contains Pantoprazole, a proton pump inhibitor used to reduce stomach acid production, primarily for conditions like peptic ulcers, GERD, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
40 mg once daily, intravenously. For Zollinger-Ellison Syndrome, initial dose may be higher and adjusted based on acid output.
Elderly
No specific dose adjustment is required for elderly patients.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment.
How to Take
Administered intravenously over 2-15 minutes, or as a continuous infusion. Reconstitute the lyophilized powder with 10 ml of normal saline.
Mechanism of Action
Pantoprazole irreversibly binds to the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, inhibiting the final step of acid secretion. This leads to a dose-dependent inhibition of both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly excreted renally (approx. 80%) and in feces (approx. 20%).
Half life
Approximately 1 hour (terminal half-life), but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after intravenous administration, bioavailability is nearly 100%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation.
- Co-administration with atazanavir or nelfinavir due to reduced antiviral efficacy.
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
Increased methotrexate levels, especially with high doses.
Ketoconazole, Itraconazole, Posaconazole, Erlotinib
Absorption of these drugs is pH-dependent and may be reduced by pantoprazole.
Storage
Store below 25°C, protect from light. Do not freeze. Reconstituted solution should be used within 2-4 hours.
Overdose
Symptoms of overdose are generally mild. Symptomatic and supportive treatment is recommended. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted into breast milk, caution advised.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation.
- Co-administration with atazanavir or nelfinavir due to reduced antiviral efficacy.
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
Increased methotrexate levels, especially with high doses.
Ketoconazole, Itraconazole, Posaconazole, Erlotinib
Absorption of these drugs is pH-dependent and may be reduced by pantoprazole.
Storage
Store below 25°C, protect from light. Do not freeze. Reconstituted solution should be used within 2-4 hours.
Overdose
Symptoms of overdose are generally mild. Symptomatic and supportive treatment is recommended. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted into breast milk, caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored as recommended.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for efficacy and safety in acid-related disorders. Post-marketing surveillance data also available.
Lab Monitoring
- Liver function tests (baseline and periodically for long-term use)
- Magnesium levels (for long-term use, especially with diuretics)
Doctor Notes
- Always ensure proper reconstitution and aseptic technique for IV administration.
- Consider lowest effective dose for shortest duration possible, especially in elderly or those with comorbidities.
Patient Guidelines
- Inform your doctor about all your medical conditions and other medications.
- Do not stop treatment abruptly without consulting your doctor.
- Report any unusual symptoms or severe side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid spicy, fatty foods, and caffeine.
- Elevate the head of your bed while sleeping if you have GERD.
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