Propin
Generic Name
Propranolol Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| propin 20 mg capsule | ৳ 5.01 | N/A |
Description
Overview of the medicine
Propin 20 mg Capsule is used to treat high blood pressure, angina, irregular heartbeats, and to prevent migraine headaches. It belongs to a group of medicines called beta-blockers.
Uses & Indications
Dosage
Adults
For hypertension: Initially 40 mg twice daily, may be increased gradually. For angina/arrhythmias/migraine: 10-40 mg 2-4 times daily.
Elderly
Lower initial doses may be appropriate; titrate slowly.
Renal_impairment
No significant dosage adjustment usually needed, but monitor carefully. Use with caution in severe renal impairment.
How to Take
Take orally, preferably before meals or on an empty stomach for better absorption, but consistently with food if stomach upset occurs. Do not crush or chew capsules.
Mechanism of Action
Propranolol is a non-selective beta-adrenergic receptor blocker. It blocks beta-1 and beta-2 adrenergic receptors, leading to decreased heart rate, myocardial contractility, and cardiac output, thereby lowering blood pressure. It also reduces renin release and has anti-arrhythmic effects.
Pharmacokinetics
Onset
Oral: 30-60 minutes
Excretion
Mainly via urine as metabolites, with a small amount of unchanged drug.
Half life
3-6 hours (immediate release)
Absorption
Rapidly and almost completely absorbed from the GI tract. Subject to significant first-pass metabolism.
Metabolism
Extensive hepatic metabolism, primarily by glucuronidation and hydroxylation.
Side Effects
Contraindications
- Bronchial asthma or bronchospasm
- Cardiogenic shock
- Sinus bradycardia
- Second or third-degree AV block
- Decompensated heart failure
- Prinzmetal's angina
Drug Interactions
NSAIDs (e.g., Ibuprofen)
May reduce the hypotensive effects of propranolol.
Insulin and oral hypoglycemics
Propranolol may mask symptoms of hypoglycemia and potentiate the hypoglycemic effect.
Alpha-blockers (e.g., Prazosin)
Increased risk of first-dose hypotension.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, heart failure, bronchospasm, and hypoglycemia. Management involves supportive measures, atropine for bradycardia, glucagon, and vasopressors for hypotension.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Bronchial asthma or bronchospasm
- Cardiogenic shock
- Sinus bradycardia
- Second or third-degree AV block
- Decompensated heart failure
- Prinzmetal's angina
Drug Interactions
NSAIDs (e.g., Ibuprofen)
May reduce the hypotensive effects of propranolol.
Insulin and oral hypoglycemics
Propranolol may mask symptoms of hypoglycemia and potentiate the hypoglycemic effect.
Alpha-blockers (e.g., Prazosin)
Increased risk of first-dose hypotension.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, heart failure, bronchospasm, and hypoglycemia. Management involves supportive measures, atropine for bradycardia, glucagon, and vasopressors for hypotension.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used for cardiovascular conditions since its introduction. Ongoing research explores new indications.
Lab Monitoring
- Blood pressure
- Heart rate
- ECG
- Blood glucose (in diabetics)
Doctor Notes
- Emphasize gradual withdrawal to avoid rebound effects.
- Caution in patients with diabetes due to masked hypoglycemia symptoms.
- Monitor for signs of heart failure.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- Take at the same time each day.
- Avoid alcohol while taking this medicine.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment. Patients should be warned not to drive or operate machinery until their reaction to the drug is known.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Manage stress through relaxation techniques.
- Avoid smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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