Prostacin
Generic Name
Tamsulosin Hydrochloride
Manufacturer
ACI Limited
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prostacin 04 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Prostacin 0.4 mg capsule is an alpha-1 adrenergic blocker used to treat the signs and symptoms of benign prostatic hyperplasia (BPH). It relaxes the muscles in the prostate and bladder neck, making it easier to urinate.
Uses & Indications
Dosage
Adults
0.4 mg once daily, taken approximately 30 minutes after the same meal each day. May be increased to 0.8 mg once daily after 2-4 weeks if needed.
Elderly
No dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Orally, once daily, approximately 30 minutes after the same meal each day. Swallow the capsule whole; do not crush, chew, or open it.
Mechanism of Action
Tamsulosin selectively blocks alpha-1A and alpha-1B adrenergic receptors in the prostate, bladder neck, and prostatic urethra. This blockade causes relaxation of the smooth muscle in these tissues, leading to improved urine flow and reduced BPH symptoms.
Pharmacokinetics
Onset
Symptomatic improvement may be observed within 2-4 weeks, though effects can be seen earlier.
Excretion
Mainly excreted in urine (about 76% as metabolites), with a small amount in feces.
Half life
Approximately 9-15 hours (terminal half-life).
Absorption
Well absorbed from the gastrointestinal tract, nearly 90% bioavailable when taken on an empty stomach. Food slightly reduces and delays absorption.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to Tamsulosin or any component of the formulation
- History of orthostatic hypotension
Drug Interactions
Other alpha-1 blockers
Increased risk of hypotension. Not recommended for concomitant use.
Strong CYP2D6 inhibitors (e.g., paroxetine)
May increase Tamsulosin exposure. Use with caution.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
Increased risk of hypotension. Use with caution, initiate PDE5 inhibitor at lowest dose.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
May increase Tamsulosin exposure. Avoid concomitant use or reduce Tamsulosin dose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe hypotension. Treatment is supportive, focusing on maintaining cardiovascular stability. Intravenous fluids and vasopressors may be necessary.
Pregnancy & Lactation
Tamsulosin is not indicated for use in women. It is contraindicated in pregnancy and lactation.
Side Effects
Contraindications
- Hypersensitivity to Tamsulosin or any component of the formulation
- History of orthostatic hypotension
Drug Interactions
Other alpha-1 blockers
Increased risk of hypotension. Not recommended for concomitant use.
Strong CYP2D6 inhibitors (e.g., paroxetine)
May increase Tamsulosin exposure. Use with caution.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
Increased risk of hypotension. Use with caution, initiate PDE5 inhibitor at lowest dose.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
May increase Tamsulosin exposure. Avoid concomitant use or reduce Tamsulosin dose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe hypotension. Treatment is supportive, focusing on maintaining cardiovascular stability. Intravenous fluids and vasopressors may be necessary.
Pregnancy & Lactation
Tamsulosin is not indicated for use in women. It is contraindicated in pregnancy and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Tamsulosin in improving urinary flow rates and reducing symptoms of BPH.
Lab Monitoring
- No specific routine lab monitoring is generally required. Blood pressure monitoring is advisable, especially at initiation.
Doctor Notes
- Advise patients about the possibility of orthostatic hypotension, especially during initiation or dose changes.
- Counsel patients regarding Intraoperative Floppy Iris Syndrome (IFIS) before cataract surgery.
- Monitor for ejaculatory disorders.
Patient Guidelines
- Take this medicine as directed by your doctor.
- Swallow the capsule whole; do not crush, chew, or open it.
- Take it approximately 30 minutes after the same meal each day.
- Be aware of potential dizziness, especially when changing positions (sitting to standing).
- Inform your doctor about any eye surgery planned, as it may cause 'Floppy Iris Syndrome'.
Missed Dose Advice
If a dose is missed, take it as soon as you remember with food. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
This medicine may cause dizziness, especially at the start of treatment or when changing dose. Do not drive or operate machinery if you experience dizziness or lightheadedness.
Lifestyle Advice
- Avoid sudden changes in position to prevent dizziness.
- Stay hydrated.
- Regular exercise may help manage BPH symptoms.
- Limit caffeine and alcohol intake.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.