Adults

Typically 1-1.5 g amino acids/kg body weight/day, adjusted based on patient's nutritional status, metabolic needs, and clinical condition. Infusion rate should not exceed 0.1 g/kg/hour.

Elderly

Lower doses may be considered, starting at 0.8-1 g/kg/day, with careful monitoring due to potential renal and hepatic impairment.

Renal_impairment

Reduced dosage and careful monitoring of electrolyte and fluid balance, often 0.5-0.7 g/kg/day, or use of specialized renal formulations. Avoid in severe renal failure without dialysis.

Onset

Immediate upon initiation of infusion.

Excretion

Metabolites (e.g., urea) are primarily excreted via kidneys. Unutilized amino acids may be excreted unchanged in urine.

Half life

Varies depending on individual metabolic rate and specific amino acids; generally utilized rapidly by tissues for protein synthesis or energy.

Absorption

Administered intravenously, hence 100% bioavailability into systemic circulation.

Metabolism

Amino acids are metabolized in various tissues, primarily the liver, into proteins, glucose, or energy, or converted to urea for excretion.

Insulin

Dosage of insulin may need adjustment as amino acids can affect glucose metabolism.

Tetracycline

May increase protein catabolism and nitrogen excretion. Not recommended for concomitant use.

Corticosteroids

May influence protein metabolism, requiring careful monitoring and potential dosage adjustments of amino acid solutions.