Proxid
Generic Name
Deflazacort
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| proxid 6 mg tablet | ৳ 2.50 | N/A |
Description
Overview of the medicine
Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant agent. It is used to treat various conditions such as Duchenne muscular dystrophy, asthma, arthritis, and allergic reactions. It has a slightly better side-effect profile compared to some other corticosteroids.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the condition and patient response. Typically, initial doses range from 6 mg to 90 mg daily, adjusted downwards for maintenance. For Duchenne muscular dystrophy, 0.9 mg/kg/day once daily.
Elderly
No specific dose adjustment for elderly patients is usually required, but caution is advised due to potential age-related organ function decline.
Renal_impairment
No specific dose adjustment is generally needed for renal impairment, but caution is advised.
How to Take
Take orally, with or without food. It is recommended to take it in the morning to align with the body's natural corticosteroid rhythm. Do not stop abruptly without consulting a doctor.
Mechanism of Action
Deflazacort binds to glucocorticoid receptors in the cytoplasm, forming a complex that translocates to the nucleus. This complex modulates gene expression, leading to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators. It also reduces immune cell activity.
Pharmacokinetics
Onset
Within a few hours.
Excretion
Mainly excreted via the kidneys (urine) as inactive metabolites.
Half life
Active metabolite half-life is approximately 1.5-2 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract and converted to its active metabolite, 21-desacetyl deflazacort.
Metabolism
Extensively metabolized in the liver to the active metabolite (21-desacetyl deflazacort) and then to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to deflazacort or any components of the tablet.
- Systemic fungal infections.
- Administration of live or live-attenuated vaccines during therapy.
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Diuretics
Increased risk of hypokalemia.
Ketoconazole, Erythromycin
May increase deflazacort's effects by inhibiting its metabolism.
Phenytoin, Phenobarbital, Rifampicin
May reduce deflazacort's effects by increasing its metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is unlikely to cause life-threatening effects. Chronic overdose can lead to signs of hypercorticism (Cushing's syndrome). Treatment is symptomatic and supportive; gradual withdrawal if chronic overdose.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Small amounts may pass into breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to deflazacort or any components of the tablet.
- Systemic fungal infections.
- Administration of live or live-attenuated vaccines during therapy.
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Diuretics
Increased risk of hypokalemia.
Ketoconazole, Erythromycin
May increase deflazacort's effects by inhibiting its metabolism.
Phenytoin, Phenobarbital, Rifampicin
May reduce deflazacort's effects by increasing its metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is unlikely to cause life-threatening effects. Chronic overdose can lead to signs of hypercorticism (Cushing's syndrome). Treatment is symptomatic and supportive; gradual withdrawal if chronic overdose.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Small amounts may pass into breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the manufacturing date, check packaging for exact details.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, original patent expired
Clinical Trials
Deflazacort has undergone extensive clinical trials for its efficacy and safety in various conditions, particularly for Duchenne muscular dystrophy, demonstrating improved motor function and reduced disease progression.
Lab Monitoring
- Blood glucose levels (especially in diabetics)
- Blood pressure
- Electrolytes (e.g., potassium)
- Bone density (long-term use)
- Growth in children (long-term use)
Doctor Notes
- Monitor patients for signs of adrenal suppression and Cushing's syndrome, especially during long-term therapy.
- Advise patients on gradual withdrawal to prevent steroid withdrawal syndrome.
- Consider calcium and vitamin D supplementation for patients on long-term therapy to mitigate osteoporosis risk.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking this medication abruptly without consulting your doctor.
- Report any unusual side effects or signs of infection to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Deflazacort may cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet, potentially low in sodium and high in potassium.
- Engage in regular weight-bearing exercise to help maintain bone density.
- Avoid exposure to people with chickenpox or measles if you haven't had them or been vaccinated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.