Prucon
Generic Name
Prucalopride
Manufacturer
Hypothetical Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prucon 2 mg tablet | ৳ 24.00 | ৳ 240.00 |
Description
Overview of the medicine
Prucon 2 mg tablet contains Prucalopride, a selective serotonin 5-HT4 receptor agonist used for the symptomatic treatment of chronic idiopathic constipation in adults for whom laxatives have failed to provide adequate relief.
Uses & Indications
Dosage
Adults
The recommended dose is 2 mg once daily, taken with or without food.
Elderly
For elderly patients, initiate treatment with 1 mg once daily. If required and well tolerated, the dose can be increased to 2 mg once daily.
Renal_impairment
For patients with severe renal impairment (creatinine clearance <30 mL/min), the recommended dose is 1 mg once daily.
How to Take
Take Prucon 2 mg tablet orally with or without food. Swallow the tablet whole with water; do not crush, chew, or break it.
Mechanism of Action
Prucalopride acts as a highly selective serotonin 5-HT4 receptor agonist. By stimulating these receptors in the gastrointestinal tract, it increases colonic motility and improves bowel transit, leading to increased stool frequency and improved stool consistency.
Pharmacokinetics
Onset
Clinical effect typically observed within 1 week of treatment initiation.
Excretion
Primarily excreted unchanged (approximately 60% of the dose) in the urine, with a smaller amount excreted in the feces.
Half life
The plasma elimination half-life is approximately 24-30 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration (Cmax) is reached in approximately 2-3 hours.
Metabolism
Minimally metabolized; primarily by CYP enzymes, but significant metabolism is not observed. Major metabolic products are inactive.
Side Effects
Contraindications
- •Hypersensitivity to the active substance or to any of the excipients.
- •Intestinal perforation or obstruction.
- •Severe inflammatory conditions of the intestinal tract such as Crohn's disease, ulcerative colitis, and toxic megacolon/megarectum.
Drug Interactions
Cyclosporine
Concomitant use with cyclosporine (a P-glycoprotein inhibitor) may increase prucalopride exposure; caution advised.
Ketoconazole
Concomitant use with ketoconazole (a potent CYP3A4 inhibitor) may increase prucalopride exposure; caution advised.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, and diarrhea. Management should be symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Not recommended during pregnancy unless clearly necessary and the potential benefit outweighs the potential risk. Prucalopride is excreted in breast milk, therefore it is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired for generic versions
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Global Brand Names
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