Prucon
Generic Name
Prucalopride
Manufacturer
Hypothetical Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prucon 2 mg tablet | ৳ 24.00 | ৳ 240.00 |
Description
Overview of the medicine
Prucon 2 mg tablet contains Prucalopride, a selective serotonin 5-HT4 receptor agonist used for the symptomatic treatment of chronic idiopathic constipation in adults for whom laxatives have failed to provide adequate relief.
Uses & Indications
Dosage
Adults
The recommended dose is 2 mg once daily, taken with or without food.
Elderly
For elderly patients, initiate treatment with 1 mg once daily. If required and well tolerated, the dose can be increased to 2 mg once daily.
Renal_impairment
For patients with severe renal impairment (creatinine clearance <30 mL/min), the recommended dose is 1 mg once daily.
How to Take
Take Prucon 2 mg tablet orally with or without food. Swallow the tablet whole with water; do not crush, chew, or break it.
Mechanism of Action
Prucalopride acts as a highly selective serotonin 5-HT4 receptor agonist. By stimulating these receptors in the gastrointestinal tract, it increases colonic motility and improves bowel transit, leading to increased stool frequency and improved stool consistency.
Pharmacokinetics
Onset
Clinical effect typically observed within 1 week of treatment initiation.
Excretion
Primarily excreted unchanged (approximately 60% of the dose) in the urine, with a smaller amount excreted in the feces.
Half life
The plasma elimination half-life is approximately 24-30 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration (Cmax) is reached in approximately 2-3 hours.
Metabolism
Minimally metabolized; primarily by CYP enzymes, but significant metabolism is not observed. Major metabolic products are inactive.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Intestinal perforation or obstruction.
- Severe inflammatory conditions of the intestinal tract such as Crohn's disease, ulcerative colitis, and toxic megacolon/megarectum.
Drug Interactions
Cyclosporine
Concomitant use with cyclosporine (a P-glycoprotein inhibitor) may increase prucalopride exposure; caution advised.
Ketoconazole
Concomitant use with ketoconazole (a potent CYP3A4 inhibitor) may increase prucalopride exposure; caution advised.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, and diarrhea. Management should be symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Not recommended during pregnancy unless clearly necessary and the potential benefit outweighs the potential risk. Prucalopride is excreted in breast milk, therefore it is not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Intestinal perforation or obstruction.
- Severe inflammatory conditions of the intestinal tract such as Crohn's disease, ulcerative colitis, and toxic megacolon/megarectum.
Drug Interactions
Cyclosporine
Concomitant use with cyclosporine (a P-glycoprotein inhibitor) may increase prucalopride exposure; caution advised.
Ketoconazole
Concomitant use with ketoconazole (a potent CYP3A4 inhibitor) may increase prucalopride exposure; caution advised.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, and diarrhea. Management should be symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Not recommended during pregnancy unless clearly necessary and the potential benefit outweighs the potential risk. Prucalopride is excreted in breast milk, therefore it is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired for generic versions
Clinical Trials
Prucalopride has undergone extensive clinical trials demonstrating its efficacy and safety profile in improving bowel function and reducing symptoms of chronic constipation in adult patients.
Lab Monitoring
- No specific routine laboratory monitoring is required for patients taking Prucon.
Doctor Notes
- Before initiating Prucon, thoroughly assess the patient for organic causes of constipation, including ruling out mechanical obstruction.
- Monitor patients for potential cardiovascular adverse events, although rare.
- Prucon is generally not recommended for patients with severe hepatic impairment.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not stop taking Prucon without consulting your doctor, even if your symptoms improve.
- Inform your doctor if you experience severe diarrhea or any unusual side effects.
- Maintain adequate fluid intake while taking this medication.
Missed Dose Advice
If a dose of Prucon is missed, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Prucon may cause dizziness or fatigue. Patients should be advised not to drive or operate machinery if they experience these symptoms.
Lifestyle Advice
- Incorporate fiber-rich foods like fruits, vegetables, and whole grains into your diet.
- Engage in regular physical activity to help stimulate bowel movements.
- Ensure adequate fluid intake throughout the day to support healthy digestion.
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