Prufit
Generic Name
Prucalopride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prufit 1 mg tablet | ৳ 14.00 | ৳ 140.00 |
| prufit 2 mg tablet | ৳ 24.00 | ৳ 240.00 |
Description
Overview of the medicine
Prufit is a medication containing Prucalopride, used to treat chronic idiopathic constipation in adults when laxatives do not provide adequate relief.
Uses & Indications
Dosage
Adults
2 mg once daily.
Elderly
2 mg once daily, consider 1 mg if needed.
Renal_impairment
1 mg once daily for severe renal impairment (CrCl < 30 mL/min).
How to Take
Take orally with or without food, preferably at the same time each day.
Mechanism of Action
Prucalopride is a selective, high-affinity serotonin (5-HT4) receptor agonist that acts on the enterochromaffin cells in the gastrointestinal tract to stimulate colonic motility and accelerate colonic transit, thereby relieving constipation.
Pharmacokinetics
Onset
Starts acting within hours, full effect within a few days.
Excretion
Mainly renal (approx 60% unchanged), some fecal.
Half life
Approximately 24-30 hours.
Absorption
Well absorbed, bioavailability approx 90%.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to prucalopride or any excipient
- Intestinal obstruction, inflammatory bowel disease (Crohn's disease, ulcerative colitis), toxic megacolon/megarectum
Drug Interactions
Rifampicin
May decrease prucalopride exposure.
Ketoconazole
Increases prucalopride exposure (adjust dose for severe renal impairment).
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, and abdominal cramps. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk, so caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to prucalopride or any excipient
- Intestinal obstruction, inflammatory bowel disease (Crohn's disease, ulcerative colitis), toxic megacolon/megarectum
Drug Interactions
Rifampicin
May decrease prucalopride exposure.
Ketoconazole
Increases prucalopride exposure (adjust dose for severe renal impairment).
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, and abdominal cramps. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk, so caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent (generic versions available)
Clinical Trials
Clinical trials demonstrated significant improvement in spontaneous complete bowel movements compared to placebo for chronic constipation patients.
Lab Monitoring
- No routine lab monitoring required.
Doctor Notes
- Emphasize lifestyle modifications (diet, fluid, exercise).
- Assess for contraindications before prescribing.
Patient Guidelines
- Take Prufit exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any unusual or severe side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or fatigue. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Incorporate a fiber-rich diet.
- Engage in regular physical activity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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