Pulmicort F
Generic Name
Budesonide and Formoterol
Manufacturer
AstraZeneca
Country
Sweden
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pulmicort f 160 mcg inhaler | ৳ 900.00 | N/A |
Description
Overview of the medicine
A combination inhaled corticosteroid and long-acting beta-2 agonist used for the maintenance treatment of asthma and COPD.
Uses & Indications
Dosage
Adults
Asthma: 1-2 inhalations twice daily (e.g., 160/4.5 mcg). COPD: 2 inhalations twice daily (e.g., 160/4.5 mcg).
Elderly
No dosage adjustment required.
Renal_impairment
No specific dosage adjustment required, but use with caution.
How to Take
For inhalation only. Shake the inhaler well before each use. Inhale slowly and deeply through the mouthpiece while activating the canister. Hold breath for 5-10 seconds. Rinse mouth with water after use to prevent oral candidiasis.
Mechanism of Action
Budesonide is an anti-inflammatory corticosteroid that reduces inflammation in the airways. Formoterol is a long-acting beta-2 agonist that relaxes the smooth muscles in the airways, leading to bronchodilation.
Pharmacokinetics
Onset
Bronchodilation with Formoterol typically within 1-3 minutes. Anti-inflammatory effects of Budesonide develop over days to weeks.
Excretion
Primarily via urine and feces as metabolites.
Half life
Budesonide: approx. 2-3 hours. Formoterol: approx. 10 hours.
Absorption
Budesonide has low systemic bioavailability due to extensive first-pass metabolism. Formoterol is rapidly absorbed after inhalation.
Metabolism
Both extensively metabolized in the liver, primarily via CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to budesonide, formoterol, or any excipients.
- Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.
Drug Interactions
Diuretics (e.g., Furosemide)
May potentiate hypokalemia.
Tricyclic antidepressants, MAOIs
May prolong the QTc interval and increase cardiovascular risk.
Beta-adrenergic blockers (e.g., Propranolol)
May antagonize the effect of formoterol.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir)
May increase budesonide systemic exposure.
Storage
Store below 30°C. Do not freeze. Keep out of direct sunlight and away from heat. Keep out of reach of children.
Overdose
Symptoms may include tremor, headache, palpitations (formoterol), and systemic corticosteroid effects (budesonide). Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Budesonide is excreted in human milk, but formoterol's presence is unknown. Use with caution during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to budesonide, formoterol, or any excipients.
- Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.
Drug Interactions
Diuretics (e.g., Furosemide)
May potentiate hypokalemia.
Tricyclic antidepressants, MAOIs
May prolong the QTc interval and increase cardiovascular risk.
Beta-adrenergic blockers (e.g., Propranolol)
May antagonize the effect of formoterol.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir)
May increase budesonide systemic exposure.
Storage
Store below 30°C. Do not freeze. Keep out of direct sunlight and away from heat. Keep out of reach of children.
Overdose
Symptoms may include tremor, headache, palpitations (formoterol), and systemic corticosteroid effects (budesonide). Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Budesonide is excreted in human milk, but formoterol's presence is unknown. Use with caution during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in asthma and COPD management, supporting its use as a maintenance therapy.
Lab Monitoring
- Regular monitoring of pulmonary function (FEV1).
- Potassium levels (if prone to hypokalemia).
- For signs of systemic corticosteroid effects.
Doctor Notes
- Emphasize proper inhaler technique to ensure optimal drug delivery.
- Advise patients to always carry their rescue inhaler for acute symptoms.
- Regular follow-up is crucial for pulmonary function assessment and side effect monitoring.
Patient Guidelines
- Use regularly as prescribed, do not stop abruptly.
- Rinse mouth with water after each use to prevent oral candidiasis.
- Not for acute asthma attacks; use a separate rescue inhaler for sudden symptoms.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose.
Driving Precautions
Generally no known effects on driving. However, if experiencing dizziness or tremor, avoid driving.
Lifestyle Advice
- Avoid smoking.
- Maintain good oral hygiene.
- Stay hydrated.
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